(LML) Neural Leprosy and Rheumatoid Arthritis

Leprosy Mailing List – June 30,  2018

Ref.:   (LML)  Neural Leprosy and Rheumatoid Arthritis

From:   Wim Theuvenet, Apeldoorn, the Netherlands

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Dear Pieter,

 

 

Thank Dr. Tahir for the mail (LML, June 28, 2018).

 

From the description one may conclude that the lady her initial symptoms indeed seem to fit the classical diagnosis of PN leprosy with type 1 (+2) reaction)!! The swollen nerves and the loss of sensation and motor function are typical!

 

The spontaneous Swan neck deformities of her fingers and the wrist involvement which developed 8 yrs later do as Dr Schreuders suggest seem to fit best the diagnosis of Rheumatoid Arthritis. RA does not cause a swelling of nerves and loss of sensation can not be expected.

Has she a limitation in MCP full extension? In combination this may be caused by tightness of the intrinsic muscles in the palm of the hand. Are these tender? Are there signs of an arthritis at wrist or MCP level? as this would further support the RA diagnosis!.

 

Suggestion:

RA serology incl anti-CCP 2 and consultation by a rheumatologist.

Handtherapist can make oval-8 splints for the affected PIP joints to address the Swanneck deformities, while at night a splint to immobilise the fingers, hand and wrist may help to lengthen the intrinsic muscles.  

In case of a RA arthritis a timely!! synovectomy of the inflamed synovia at wrist and MCP levels and of inflamed synovia around the tendons can often reduce pain and help in preventing more damage to the joints and in the rupturing of the inflamed tendons!

 

When any doubts remain please do not hesitate to contact again, we are interested in further developments!

 

With best regards,

 

Willem J.Theuvenet, M.D., Ph.D

Reconstructive Hand surgeon/ Leprologist

 

 

 

 

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 

 

(LML) Neural Leprosy and Rheumatoid Arthritis

Leprosy Mailing List – June 28,  2018

Ref.:   (LML)  Neural Leprosy and Rheumatoid Arthritis

From:   Tahir Dahiru, Kanu, Nigeria

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Dear Pieter Schreuder,

 

I write to find out whether Neural Leprosy and Rheumatoid Arthritis are mutually exclusive to each other.

 

The reason why this question is being asked is that a 24-year old lady who just her first child had presented to a Leprosy OPD with multiple nerve enlargements, nerve tenderness and loss of nerve function of both motor and sensory nerves affecting the ulnar, median, posterior tibial and common peroneal nerves. She never had any obvious skin lesion suggestive of Leprosy.  A provisional diagnosis of Neural Leprosy with severe type 1 Lepra reaction was made. Patient was placed on MDT for 12 months and commenced on a standard course of prednisolone.

 

Eight years later she presented to a different Doctor with Swan neck deformities and wrist involvement. The initial diagnosis of Pure Neural Leprosy was being questioned. 

 

Can anybody advise me on this?

 

 

Thanks,

 

 

Tahir Dahiru

 

 

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 

(LML) Manifest against the implementation of MDT-U

Leprosy Mailing List – June 25,  2018

Ref.:   (LML) Manifest against the implementation of MDT-U  

From:  P. Narasimha Rao, Hyderabad, India

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Dear Pieter,

 

Ref: Mail from Claudio Salgado, Brazil, manifesto against the implementation of U-MDT. LML June 12, 2018.

 

Let me first congratulate President Dr. Claudio Salgado & executive of Brazilian leprosy society and all other medical societies for bringing forth lack of evidence and hazards in introduction of UMDT in that country. It is very unfortunate that authorities in Brazil are planning to going ahead with introduction of this unscientific UMDT based on specious logic. Any effort to stop this unwarranted shortening of existing MDT regimen by 6 months for MB patients is welcome and should be supported all concerned.  

 

India and Brazil are two countries with large leprosy populations. Such short-sighted policy changes by authorities, without taking into consideration the ground realities, is very detrimental to the program, which is already reeling under in-attention, lack of expertise & funding. 

 

The idea of U-MDT which was proposed in 2002 without any scientific basis by WHO, generated lot of criticism across the world. The authorities unrelenting as they were, went ahead to 'create evidence' in its support by initiating and funding a multicenter study with a conveniently poor design and distrustful end points. Any careful reader, why even a casual reader, of those final reports from china and India can easily understand how poor is the quality of evidence generated through them. And Dr Claudio has mentioned eloquently how the evidence was generated in Brazil to support U-MDT through various papers over last few years. 

 

In 2017, there was a high level technical member committee meeting held in India, involving WHO, NLEP and other experts, one of the agenda being to push forward with U-MDT. Fortunately, the opinion was rallied against its implementation, due to the efforts of many leprosy workers and scientists of India, who saw the harm to program in introduction of UMDT in NLEP. There is a real danger that there will be efforts to push U-MDT forward once again, as it was introduced in Brazil already. 

 

What is very surprising is, same members of international community who opposed U-MDT vehemently in beginning, for reasons unknown, prefer to be silent now, while U-MDT is being pushed in to the national / global leprosy programs.  As evidence to such a thought, we can look at the WHO Global leprosy 2016-2020 document, wherein U-MDT implementation proposal is mentioned at least at three sperate areas of the document. We saw that happen once before, during 2003-2005 while 'final push' of leprosy was being implemented all over world, especially in India. We all know how the program managers brought down the numbers! World community of leprosy was a silent witness to it and did nothing then, only to write many-a-article wondering why it was done, how we all let it happen, years later! It is time we don't do the same and repeat the history. 

 

As a person who diagnoses leprosy and manages them on daily basis, I am often amazed why WHO is in such a hurry to damage the program which is running so successfully world over!   I am sure, if contacted, majority of 10,000 dermatologists and leprologists of India will vouch that they continue to see MB leprosy regularly, even in increased numbers every day, even today. 

 

If U-MDT is introduced in India too, which is not unlikely in near future, there will not be a more unfortunate day for leprosy patients of India.  This unwise move to introduce U-MDT in the national program does not benefit the end user, the leprosy patient at all!  And none of the authorities involved in pushing this hazardous change seem to comprehend this truth! 

 

Here in I am enclosing as attachment a letter written by IADVL to NLEP/ Govt of India in 2007 and a paper published in IDOJ regarding the potential harm in introducing U-MDT in India. 

 

I wish and hope that wisdom will prevail and U-MDT would not replace the present WHO MDT.  As a president-elect of IADVL, I will do my best through the office of IADVL, to resist such a move in India, which without doubt is detrimental to the leprosy program and more importantly to the individual patient. 

 

 

with Best regards, 

 

P. Narasimha Rao, MD, D.D, PhD

President- Elect, National IADVL 2018

 

dermarao@gmail.com

 

Phone- 040-23514566

Mobile-09849044898

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 

(LML) InfoNTD monthly mail with the latest publications on cross-cutting issues and NTDs - June 2018

 

Leprosy Mailing List – June 20,  2018

Ref.:  (LML)   InfoNTD monthly mail with the latest publications on cross-cutting issues and NTDs - June 2018

From:  Ilse Egers, Amsterdam, the Netherlands

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Dear LML readers,

This newsletter provides you with a selection of news items and recent publications on cross-cutting issues in NTDs. Our starting point is to add articles covering a wide variety of issues. Unfortunately, this is not always possible due to a limited diversity in and shortage of articles on cross-cutting issues and NTDs. Feel free to contact us with any questions or to receive the PDF if a link to the full text is not included. Our document delivery service is free! Ilse Egers InfoNTD Information officer infontd@leprastichting.nl

 

 

News Submit your photos to the Beat NTDs photo contest. NNN is partnering with the Royal Society of Tropical Medicine and Hygiene to launch a photo competition to find the most engaging photographic representation of the work being done to prevent, control, treat and eliminate neglected tropical diseases (NTDs) around the world. Read more

 

 

 

 

 

New publications

 

 

Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects. Chandrasena N, Premaratna R, Gunaratna IE, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006472. Abstract Sri Lanka was acknowledged to have eliminated lymphatic filariasis (LF) as a public health problem in 2016, largely due to its success in Mass Drug Administration (MDA) to interrupt disease transmission. Analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT) of the national Morbidity Management and Disability Prevention (MMDP) program was carried out with the objective of evaluating it and providing recommendations to optimize the use of available resources. Download PDF Interactions between ecological and socio-economic drivers of Buruli ulcer burden in sub-Saharan Africa: Opportunities for improved control. Garchitorena A, Bonds MH, Guegan J-F, et al. Ecology and Evolution of Infectious Diseases: pathogen control and public health management in low-income countries. 2018. Download PDF (S)WASH-D for Worms: A pilot study investigating the differential impact of school- versus community-based integrated control programs for soil-transmitted helminths. Clarke NE, Clements ACA, Amaral S, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006389. Abstract Soil-transmitted helminths (STH) infect nearly 1.5 billion individuals globally, and contribute to poor physical and cognitive development in children. STH control programs typically consist of regular delivery of anthelminthic drugs, targeting school-aged children. Expanding STH control programs community-wide may improve STH control among school-aged children, and combining deworming with improvements to water, sanitation and hygiene (WASH) may further reduce transmission. Download PDF A holistic approach to the mycetoma management. Bakhiet SM, Fahal AH, Musa AM, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006391. Abstract Mycetoma is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep structures and bone resulting in massive damage, deformities and disabilities. In this communication, the Mycetoma Research Center (MRC), Sudan shares its experience in implementing a new holistic approach to manage mycetoma patients locally at the village level. Download PDF Integrated morbidity mapping of lymphatic filariasis and podoconiosis cases in 20 co-endemic districts of Ethiopia. Kebede B, Martindale S, Mengistu B, et al. PLoS Negl Trop Dis. 2018:28. Abstract Lymphatic filariasis (LF) and podoconiosis are neglected tropical diseases (NTDs) that pose a significant physical, social and economic burden to endemic communities. Patients affected by the clinical conditions of LF (lymphoedema and hydrocoele) and podoconiosis (lymphoedema) need access to morbidity management and disability prevention (MMDP) services. Clear estimates of the number and location of these patients are essential to the efficient and equitable implementation of MMDP services for both diseases. Download PDF Elimination of lymphatic filariasis as a public health problem from the Cook Islands. Ave C, Kapa RD, Ottesen E. Trop Med Health. 2018; 46(12). Abstract The Cook Islands has a long history of high-endemicity lymphatic filariasis (LF) transmitted by vector mosquitoes. Though the infection prevalence had declined between 1975 and 1999 following episodic treatment activities, still infection was widespread with pockets of persistent infection. Beginning in 1999, the Cook Islands embarked on a national program, in partnership with Pacific Programme to Eliminate LF (PacELF), to eliminate LF as a public health problem. Download PDF Trachoma elimination: Approaches, experiences and performance of interventions in Amhara Regional State, Ethiopia. Andualem B, Beyene B, Kassahun M, et al. J Eye Dis Disord. 2018; 4(1):1-6. Abstract Trachoma is caused by conjunctival infection with a Bacteria, Chlamydia trachomatis. According to WHO grading system trachomatous trichiasis (TT), leads to irreversible blindness. Amhara national state of Ethiopia has the highest burden of TT. Despite huge efforts the region has big backlog and far from the target. Download PDF Stigma and increase of leprosy cases in SouthEast Sulawesi Province, Indonesia. Tosepu R, Gunawan J, Effendy DS, et al. Afr Health Sci. 2018; 18(1):29-31. Download PDF Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature. Budge PJ, Herbert C, Andersen B, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006454. Abstract WHO's Global Programme to Eliminate Lymphatic Filariasis (LF) uses mass drug administration (MDA) of anthelmintic medications to interrupt LF transmission in endemic areas. Recently, a single dose combination of ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB) was shown to be markedly more effective than the standard two-drug regimens (DEC or IVM, plus ALB) for achieving long-term clearance of microfilaremia. Download PDF Active case-finding and enhanced data collection to identify neglected tropical diseases. Nhlabatsi N, Lokotfwako V, Mabundza D, et al. Online J Public Health Inform. 2018; 10(1). Abstract Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It is a contagious disease that affects the skin, mucous membrane, and nerves causing discoloration and lumps on the skin and in severe cases disfigurement and deformities. Progress in the fight against leprosy has been one of the greatest public health success and in the country, was eliminated in the mid-1990s. However on the 22nd August 2017 a confirmed leprosy cases was reported by the National Referral Hospital. Read more Study of lymphoedema of non-filarial origin in the northwest region of Cameroon: spatial distribution, profiling of cases and socio-economic aspects of podoconiosis. Wanji S, Kengne-Ouafo JA, Deribe K, et al. Int Health. 2018. Abstract Although podoconiosis is endemic in Cameroon, little is known about its epidemiology and spatial distribution. This study provides an insight into the geographical distribution and epidemiology of podoconiosis in the North West region of Cameroon, yet management is limited. Evidence-informed targeted interventions are needed to manage people with lymphoedema. Read more Integrated morbidity mapping of lymphatic filariasis and podoconiosis cases in 20 co-endemic districts of Ethiopia. Kebede B, Martindale S, Mengistu B, et al. PLoS Negl Trop Dis. 2018:28. Abstract Lymphatic filariasis (LF) and podoconiosis are neglected tropical diseases (NTDs) that pose a significant physical, social and economic burden to endemic communities. Patients affected by the clinical conditions of LF (lymphoedema and hydrocoele) and podoconiosis (lymphoedema) need access to morbidity management and disability prevention (MMDP) services. Clear estimates of the number and location of these patients are essential to the efficient and equitable implementation of MMDP services for both diseases. Download PDF Cutaneous leishmaniasis in Morocco: psychosocial burden and simplified diagnosis. Bennis I. Institute of Tropical Medicine Antwerp. 2018:248. Abstract Cutaneous leishmaniasis (CL) is a neglected tropical disease (NTD) affecting more than one million persons worldwide. In Morocco, reporting over the past decade on average more than 4000 cases per year, CL is considered a public health problem. CL is mainly poverty-related in Morocco. Our research aimed to document the psychosocial burden of CL in these regions, and to assess a new diagnostic tool for CL that is appropriate for use in remote endemic areas. Download PDF Prevalence of active trachoma among children between 1-9 years, in Woliso Town, Central Ethiopia. Adamu Y, Fereji S. Ethiop J Health Dev. 2018; 32(2):1-6. Abstract Trachoma is the leading cause of preventable blindness worldwide. Communities with endemic trachoma usually live in unhygienic/unclean and dusty areas and are associated with poverty, poor sanitation, and low socioeconomic status. The objective of this study was to assess the prevalence of active trachoma among children between 1-9 years old in Woliso town, central Ethiopia. Download PDF New insights into leishmaniasis in the immunosuppressed. Akuffo H, Costa C, van Griensven J, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006375. Abstract Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. Download PDF Youth participatory research and evaluation to inform a Chagas disease prevention program in Ecuador. Marco-Crespo B, Casapulla S, Nieto-Sanchez C, et al. Eval Program Plann. 2018. Abstract This qualitative study engaged a group of young people in participatory research and evaluation activities in order to study to what extent engaging youth in health interventions can inform research and evaluation processes. We applied a youth participatory research and evaluation approach (PRE) to inform research and evaluation on the impact of a Chagas disease control program in southern Ecuador. Read more Epidemiology of soil transmitted helminth infections in the middle-belt of Ghana, Africa. Adu-Gyasi D, Asante KP, Frempong MT, et al. Parasite Epidemiol Control. 2018. Abstract Helminths are among the most widespread infectious agents prevalent in tropical and sub-tropical regions of the developing world defined by inadequate sanitation, poverty and unsafe water sources. This study was carried out to describe the distribution of helminth and malaria parasite infections in the middle-belt of Ghana in sub-Saharan Africa where disease burden, including anaemia is rife and helminths are perceived to be significant contributors of the burden. Download PDF Risk factors for buruli ulcer in a referral mission hospital in anambra state, Nigeria: A case control study. Adogu POU, Igwe JC, Chineke HN, et al. Edorium J Public Health. 2018; 5:1-9. Abstract Buruli ulcer can cause permanent disability and deformity which may severely limit a person's ability to carry out normal daily activities. The associated stigma may greatly restrict the social participation by affected persons. Though early detection and adequate medical and surgical treatment can minimize future disability and complication, recognizing the risk factors of this disease can lead to adoption of appropriate preventive strategies. Download PDF

 

 

Events Snakebite: From Science to Society June 21-22, Leiden, The Netherlands Naturalis Biodiversity Center Naturalis organises a 2-day international conference 'Snakebite : from science to society' to draw attention to a devastating, neglected tropical disease and to ignite international action on snakebite prevention and treatment. By bringing together science, government, industry and societal & humanitarian aid organisations, we want to take the first steps in developing solutions for the issues concerning snakebites in the tropics.   GDPR & the InfoNTD newsletter New EU data protection regulations came into force on 25 May. We have been reviewing our practices with regards to the GDPR, including our privacy policy and mailing list. InfoNTD sends out monthly e-mails to its subscribers with an overview of recent publications on NTDs and cross-cutting issues. The purpose of this activity is to keep subscribers up to date. InfoNTD will only process the data we have (names, email addresses) for the purpose of sending you the newsletter. We take your security seriously and will never share your contact details with anyone else. We hope the content from the InfoNTD newsletter is useful to you, but you can update your preferences or unsubscribe from this list at any time.   LML - S Deepak, B Naafs, S Noto and P Schreuder LML blog link: http://leprosymailinglist.blogspot.it/ Contact: Dr Pieter Schreuder << editorlml@gmail.com

(LML) Infolep monthly e-mail with the latest publications on leprosy - June 2018

Leprosy Mailing List – June 19,  2018

Ref.:  (LML) Infolep monthly e-mail with the latest publications on leprosy  - June 2018

From:  Jiske Erlings, Amsterdam, the Netherlands

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Dear colleagues,  Below you will find our monthly overview of recent publications on leprosy. Did you know that the Infolep portal gives you access to over 27,870 publications on leprosy? Feel free to contact me to receive the full text versions if a link to the full text is not included or for assistance with your literature research. You are invited to send us your publications on leprosy or material on leprosy in your language for inclusion in the portal. With warm regards, Jiske Erlings, j.erlings@leprastichting.nl Infolep Information officer

 

 

Highlighted publications

 

 

Report of the informal consultation on stopping discrimination and promotion inclusion of persons affected by Leprosy, New Delhi, 14-16 Nov 2017. http://apps.who.int/iris/handle/10665/272637 Forgotten People: A judicial apology for leprosy patients in Japan. Tsuji Y. Or Rev Int L. 2018. Download Recognizing neglected tropical diseases through changes on the skin : A training guide for front-line health workers. WHO/Department of control of neglected tropical diseases. 2018 Download PDF Perakslis ED. Using digital health to enable ethical health research in conflict and other humanitarian settings. Confl Health. 2018 May 14;12:23. Review. Download PDF Uncertainty, anxiety, frugality - Dealing with leprosy in the Dutch East Indies, 1816–1942. van Bergen Leo. 2018. NUS Press. Read abstract

 

 

New publications

 

 

Nerve growth factor and pathogenesis of leprosy: review and update. Aarão TLS, de Sousa JR, Falcão ASC, et al. Front Immunol. 2018 May 7;9:939. Download PDF   Perceived stigma in people affected by leprosy in leprosy village of Sinatala, Tangerang District, Banten Province, Indonesia. Astutik E, Gayatri D. Kesmas: National public health journal. 2018; 12(4). Read abstract   Spatial analysis of reported new cases and local risk of leprosy in hyper-endemic situation in north-eastern Brazil. Barbosa CC, do Bonfim CV, de Brito CMG, et al. Trop. Med. Int. Health. 2018. Read abstract   Clinical and histological profile of leprosy patients at rural based tertiary care centre in post elimination era. Bindal T, Kalra IK, Garg M, et al. APALM. 2018; 5(4):A289-A295. Download PDF   Minimum requirements and optimal testing strategies of a diagnostic test for leprosy as a tool towards zero transmission: A modeling study. Blok DJ, de Vlas SJ, Geluk A, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006529. Download PDF   Two cases of delayed diagnosis of leprosy in Mauritania. Boushab BM, Fall-Malick F-Z, Basco LK. Case Rep Dermatol Med. 2018:4. Download PDF   Leprosy in Colombia. Cardona-Castro N. Curr Trop Med Rep. 2018. Read abstract   Coexistence of nerve enlargement and neuratrophy detected by ultrasonography in leprosy patients. Chen X, Zhang L, Huang M, et al. Sci Rep. 2018; 8(1):11. Download PDF   In situ T regulatory cells and Th17 cytokines in paired samples of leprosy type 1 and type 2 reactions. Costa MB, Hungria EM, Freitas AA, et al. PLoS One. 2018 Jun 8;13(6):e0196853. Download PDF   Dependence on others for oral hygiene and its association with hand deformities and functional impairment in elders with a history of leprosy. Ferreira RC, Gonçalves TX, Soares ARDS, et al. Gerodontology. 2018. Read abstract   Relationship between levels of nutrients and habitual coffee consumption and the incidence of anemia in former leprosy patients. Ginting S, Sidabutar S, Renaldi Sihombing ES. Int J Community Med Public Health. 2018; 5(6):2199-2204. Download PDF   "Rapid impact" 10 years after: The first "decade" (2006-2016) of integrated neglected tropical disease control. Hotez PJ, Fenwick A, Ray SE, et al. PLoS Negl Trop Dis. 2018 May 24;12(5):e0006137. Download PDF   Mycobacterium leprae- specific antibodies in multibacillary leprosy patients decrease during and after treatment with either the regular 12 doses multi-drug therapy (MDT) or the uniform 6 doses MDT. Hungria EM, Bührer-Sékula S, Oliveira RM, et al. Front Immunol. 2018. Download PDF   A case-control study comparing the Dermatology Life Quality Index (DLQI) ratings of patients undergoing leprosy treatment, people cured of leprosy, and controls in Vietnam. Hunt WTNH, Hùng NT, Tru'ò'ng NN, et al. Lepr Rev. 2018; 89(1):46-55. Download PDF   Nuclear Whole-Body Bone Scanning for Leprosy. Joob B, Wiwanitkit V. Proc (Bayl Univ Med Cent). 2018 Apr 11;31(2):253. Download PDF   Biomimetic Solid Lipid Nanoparticles of Sophorolipid Designed for Anti-Leprosy Drugs. Kanwar R, Gradzielski M, Mehta SK. J Phys Chem B. 2018 Jun 6. Read abstract   Leprosy profiles in post elimination stage: Experience at a tertiary care hospital. Kilikdar M, Gedam D, Pisey A, et al. Natl J Integr Res Med. 2018; 9(2):64-67. Download PDF   Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans. Krause-Kyora B, Nutsua M, Boehme L, et al. Nat Commun. 2018 May 1;9(1):1569. Download PDF   Ensuring no one is left behind: Urgent action required to address implementation challenges for NTD control and elimination. Krentel A, Gyapong M, Ogundahunsi O, et al. PLoS Negl Trop Dis. 2018 Jun Download PDF   Effectiveness of the retreatment of patients with multibacillary leprosy and episodes of erythema nodosum leprosum and/or persistent neuritis: a single-center experience. Lastória JC, Almeida TSC, Putinatti MSMA, et al. An Bras Dermatol. 2018 Mar;93(2):181-184. Download PDF   Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention. Lockwood DNJ, Krishnamurthy P, Kumar B, et al. PLoS Negl Trop Dis. 2018 Jun 7;12(6):e0006403. Download PDF   Tuberculosis and leprosy coinfection: A perspective on diagnosis and treatment. Magnum L, Kilpatrick D, Stryjewska B. et al. Open Forum Infectious Diseases. Download PDF   The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016. Martins-Melo FR, Carneiro M, Ramos AN Jr, et al. PLoS Negl Trop Dis. 2018 Jun 4;12(6):e0006559. Download PDF   Autophagy impairment is associated with increased inflammasome activation and reversal reaction development in multibacillary leprosy. De Mattos Barbosa MG, Silva BJA, Assis TQ, et al. Front Immunol. 2018. Read abstract   Policy Lessons From Quantitative Modeling of Leprosy. Medley GF, Blok DJ, Crump RE, et al. Clin Infect Dis. 2018 Jun 1;66(suppl_4):S281-S285. Download PDF   The Genome Sequence of a SNP Type 3K strain of Mycobacterium leprae isolated from a 7th Century Hungarian case of Lepromatous Leprosy. Mendum TA, Michael Taylor G, Donoghue HD, et al. Int J Osteoarchaeol. 2018. Read abstract   World leprosy day 2018: How forward respecting the past? Naafs B. Indian J Med Res. 2018 Jan;147(1):1-3. Download PDF   Serum interleukin-6 and interferon-γ in patients with leprosy. Nada E, El Taieb M, Fayed H, et al. Egypt J Dermatol Venerol. 2018. Read abstract   Anti-lipoarabinomannan specific salivary IgA as prognostic marker for leprosy reactions in patients and cellular immunity in contacts. Nahas AA, Sousa Lima MI, Goulart IM, et al. Front Immunol. 2018. Read abstract   Active case-finding and enhanced data collection to identify neglected tropical diseases. Nhlabatsi N, Lokotfwako V, Mabundza D, et al. Online J Public Health Inform. 2018; 10(1). Read abstract   Mid-borderline leprosy masquerading as an overlap syndrome. Pawar M, Zawar V. Rheumatology (Oxford). 2018 Apr 27. Read abstract   Engineered biomarkers for leprosy diagnosis using labeled and label-free analysis. de Santana JF, da Silva MRB, Picheth GF, et al.Talanta. 2018 Sep 1;187:165-171. Read abstract   Molecular, immunological and neurophysiological evaluations for early diagnosis of neural impairment in seropositive leprosy household contacts. Santos DFD, Mendonça MR, Antunes DE, et al. PLoS Negl Trop Dis. 2018; 12(5):e0006455. Download PDF   Interpretation of nerve conduction study in polyneuropathy with multibacillary leprosy type 2 reaction. Sari DT, Widasmara D, Kurniawan SN. Malang Neurology Journal. 2018; 4(2):86-95. Download PDF   Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe. Schuenemann VJ, Avanzi C, Krause-Kyora B, et al. PLoS Pathog. 2018 May 10;14(5):e1006997. Download PDF   Study of S100 immunostaining in demonstrating neural granulomas in paucibacillary leprosy. Shenoy N, Gopinathan Nair N. Indian J Dermatol. 2018; 63(3):215-219. Download PDF   Insights into the skin microbiome dynamics of leprosy patients during multi-drug therapy and in healthy individuals from Brazil. Silva PES, Reis MP, Ávila MP, et al. Sci Rep. 2018 Jun 8;8(1):8783. Download PDF   Mycobacterium lepromatosis lepromatous leprosy in US citizen who traveled to disease-endemic areas. Singh AV, Chauhan DS. Emerg Infect Dis. 2018 May;24(5):951-952. Download PDF   Leprosy-associated chronic wound management using biomaterials. Sivasubramanian S, Mohana S, Maheswari P, et al. J Global Infect Dis. 2018; 10(2):99-107. Download PDF   Nerve growth factor and pathogenesis of leprosy: review and update. Sousa JR, Aarão TS, Falcão AS, et al. Front Immunol. 2018. Download PDF   Interaction between leprosy and HIV infection. Sudarsa P, Karna RV, Rusyati LM. Bali dermatology and venereology journal. 2018; 1(1):13-15. Download PDF   Leprosy in Children: Needs for Active Intervention. Thangaraju P, Venkatesan S. Chin Med J (Engl). 2018 Jun 5;131(11):1385. Download PDF   A prospective study to validate various clinical criteria used in classification of leprosy: a study from a tertiary care center in India. Thapa M, Sendhil Kumaran M, Narang T, et al.Int J Dermatol. 2018 May 29. Download PDF   Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy. Tiwari R, Tiwari G, Wal P, et al. Open Nanomed J. 2018; 5:1-15. Download PDF   Stigma and increase of leprosy cases in SouthEast Sulawesi Province, Indonesia. Tosepu R, Gunawan J, Effendy DS, et al. Afr Health Sci. 2018; 18(1):29-31. Download PDF   Effectiveness of traditional healers in program to control leprosy in Nagan Raya District in Aceh. Usman S, Alamsyah T, Yusuf M, et al. Dermatol Res Pract. 2018:1-12. Download PDF   Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae. Vedithi SC, Malhotra S, Das M, et al. Sci Rep. 2018 May 23;8(1):8250. Download PDF   Leprosy: A Time for Elimination by 2020. Verjee MA. 2018; 2(2):3. Download PDF   Histopathological and clinical study of leprosy cases in semi urban and rural India. Viswanathan K. Indian journal of research. 2018; 7(3):45-46. Download PDF   Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese. Wang D, Fan Y, Malhi M, et al. Am J Hum Genet. 2018 Apr 20. Read abstract   Discovery of four exonic and one intergenic novel susceptibility loci for leprosy. Wang Z, Mi Z, Wang H, et al. Clin Genet. 2018 May 3. Read abstract   Skin disease prevalence study in schoolchildren in rural Côte d'Ivoire: Implications for integration of neglected skin diseases (skin NTDs). Yotsu RR, Kouadio K, Vagamon B, et al. PLoS Negl Trop Dis. 2018 May 17;12(5):e0006489. Download PDF

 

 

Journals & Newsletters

 

 

Disability, CBR & Inclusive Development: http://dcidj.org/ Hansenologia Internationalis: http://www.ilsl.br/revista/atual.php Indian Journal of Leprosy: http://www.ijl.org.in/index.html  Leprosy Review: https://www.lepra.org.uk/Pages/FAQs/Category/volume-89 Leprosy Review Repository (1928-2001) : http://leprev.ilsl.br/arquivo.php Plos Neglected Tropical Diseases: http://journals.plos.org/plosntds/   Revista de Leprología: http://www.leprosy-information.org/resource/revista-de-leprologia   WHO Goodwill Ambassador's Newsletter for the elimination of leprosy: http://www.smhf.or.jp/e/ambassador/index.html

 

 

Websites & Services

 

 

WHO Global Leprosy Programme http://www.who.int/lep/en/ & http://www.searo.who.int/entity/global_leprosy_programme/en/ The Global Partnership for Zero leprosy http://zeroleprosy.org/ LML - Leprosy Mailing List - a free moderated email list that allows all persons interested in this theme to share ideas, information, experiences and questions. http://leprosymailinglist.blogspot.nl/ InfoNTD - Information on cross-cutting issues in Neglected Tropical Diseases (NTDs) https://www.infontd.org/

 

 

GDPR & the Infolep newsletter

 

 

New EU data protection regulations came into force on 25 May. We have been reviewing our practices with regards to the GDPR, including our privacy policy and mailing list. Infolep sends out monthly e-mails to its subscribers with an overview of recent publications on leprosy. The purpose of this activity is to keep subscribers up to date. Infolep will only process the data we have (names, email addresses) for the purpose of sending you the newsletter. We take your security seriously and will never share your contact details with anyone else. We hope the content from the Infolep newsletter is useful to you, but you can update your preferences or unsubscribe from this list at any time.

 

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com