Dapsone related complications: hypersensitivity and toxicity

Leprosy Mailing List, July 3rd, 2009
Ref.: Dapsone related complications: hypersensitivity and toxicity.
From: Dhakal K. P., Kathmandu, Nepal

Dear Ariyawansa,

Thank you very much for your message (LML June 22nd, 2009).

The case presented by you is almost definitely the case of dapsone related complication. You have not mentioned about pruritus and relevant skin presentations which are the commonest presentations of dapsone hypersensitivity which ranges from mild pruritus with some skin rashes to severe exfoliative dermatitis. I have successfully treated many cases of dapsone hypersensitivity with somewhat similar presentation like your case but with associated with skin manifestations and pruritus. In this case presented by you, it seems to be dapsone toxicity which is very different from hypersensitivity reaction. In the case presented by you, there is high chance of dapsone related complication but at the same time we can look for any other accompanying pathology.

Dr K P Dhakal

NLR

Kathmandu, Nepal