Clofazimine in ENL

Leprosy Mailing List – September 22nd, 2010

Ref.:   Clofazimine in ENL

From: Willem Theuvenet, Apeldoorn, The Netherlands

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Dear Salvatore,

In addition to the valuable comments of Pieter Schreuders and Ben Naafs (LML Sept. 2^nd 2010): I fully agree on their comments.  Perhaps a word of caution in those cases of chronic recurrent ENL when a prolonged regime of Clofazamine needs to be combined with corticosteroids.  In that situation there is definitely an increased risk of drug induced gastro-intestinal bleeding.  This risk is further increased when analgetics are added. 

These patients should be carefully monitored for this potential life threatening complication.

With best regards,

Willem Theuvenet