Zinc supplementation in the treatment of erythema nodosum leprosum (ENL) reaction?

 

Leprosy Mailing List – November 11^th, 2012

Ref.:    Zinc supplementation in the treatment of erythema nodosum leprosum (ENL) reaction?
From:  CR Revankar, New Jersey, USA

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Dear Dr Zunarsih,

 

Thank you for your message [LML Nov. 7^th, 2012].  Herewith I am sending you one old reference in Leprosy in India 1983 which I could locate immediately.  You may find this journal in National Leprosy Training Center in Makasar.  Other members of LML may provide you additional references.

 

" << Lepr India. 1983 Jul;55(3):547-52.

Oral zinc in recurrent Erythema Nodosum Leprosum reaction.

Mathur NK, Bumb RA, Mangal HN.

Abstract

Oral zinc sulfate was tried in eight cases of recurrent Erythema Nodosum Leprosum.  To control ENL, they required high dosage of clofazimine and steroids for prolonged periods.  After instituting oral zinc, the dose of clofazimine could be reduced to 100 mg twice a week and steroids could be withdrawn completely.  Four out of five patients, who were not tolerating dapsone earlier, started tolerating dapsone.  Incidence and severity of subsequent ENL was also reduced. >> "

 

Best regards,

CR Revankar

New Jersey, USA

 

 

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