Leprosy Mailing List – January 19, 2014
Ref.: (LML) DDS syndrome
From: David M. Scollard, Baton Rouge, Louisiana, USA
Dear Pieter,
Regarding the dapsone syndrome, the following article was published recently in the New England Journal of Medicine, describing a genetic association with this syndrome. The research was done in China and it appears that individuals of Chinese ancestry may be more likely to carry the allele(s) that put them at risk for this syndrome.
Zhang F.-R., Liu H., Irwanto A., et al.
HLA-B*13:01 and the Dapsone Hypersensitivity Syndrome
N Engl J Med 2013; 369:1620-1628
Dapsone is an important medication for the treatment of leprosy, but a life-threatening drug hypersensitivity syndrome develops in some patients. In this report from China, an HLA-B locus is identified as a strong genetic risk factor for the syndrome.
Best wishes,
David
David M. Scollard, M.D., Ph.D.
Director
National Hansen’s Disease Programs
Tel: 225-756-3713 or 225-756-3776
Fax: 225-756-3819 (Clinical) or 225-756-3806 (Administration)
E-mail: dscollard@hrsa.gov
Web: www.hrsa.gov/hansens
Online Course: http://www.hrsa.gov/hansensdisease/onlinecourseawareness.html
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << editorlml@gmail.com
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