Fw: LML) Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.

 

Leprosy Mailing List – February 18,  2020

Ref.:  LML)   Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.

From:  Ben Naafs, Munnekeburen, the  Netherlands

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Dear Pieter,

 

As clinician and researcher in the past I hoped and expected that the understanding the immune-system of host would lead us in the management of leprosy patients. I did but not directly. May be like the media I am too early to point at a breakthrough achieved by the group around Annemieke Geluk and Tom Ottenhoff:

 

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study.

 

Maria Tió-Coma,1 Anouk van Hooij,1 Kidist Bobosha,1,3 Jolien J. van der Ploeg-van Schip,1 Sayera Banu,4 Saraswoti Khadge,5 Pratibha Thapa,5 Chhatra B. Kunwar,5 Isabela M. Goulart,6 Yonas Bekele,3 Deanna A. Hagge,5 Milton O. Moraes,7 Rosane M. B. Teles,8 Roberta Olmo Pinheiro,7 Erik W. van Zwet,2 Jelle J. Goeman,2 Abraham Aseffa,3 Mariëlle C. Haks,1 Tom H. M. Ottenhoff,1 Robert L. Modlin,8,9 and Annemieke Geluk

 

Sci Rep. 2019; 9: 17931. Published online 2019 Nov 29. doi: 10.1038/s41598-019-54213-y

PMCID: PMC6884598  PMID: 31784594.

 

I enclosed this open source paper for discussion. I do not think that at present it will beat the experienced clinician. But it may be of help (adapted to a simpler affordable test) in the future.

 

Regards,

 

Ben Naafs

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 

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