Fw: Ref.: (LML) Smear positivity after one year course of MB MDT

 

Leprosy Mailing List – August 24,  2021

 

Ref.:  (LML) Smear positivity after one year course of MB MDT

From:  David Scollard, Baton Rouge, USA

 

 

Dear Pieter, 

 

In response to Dr. Rao's concern about visible bacilli after 1 year of MDT, I agree with Wim and others. For a convincing visual demonstration of this I recommend that he look at the Pathology chapter of the International Textbook of Leprosy, (internationaltextbookofleprosy.org), where he can see a series of photomicrographs of annual biopsies from an LL patient receiving MDT. 

 

Only a small decline in number was seen after one year. MDT was continued for another year and still many bacilli were present. MDT was stopped at that time, on the understanding that all bacilli were dead.  The number of bacilli continued to decline slowly over the next few years. 

 

MDT kills M leprae effectively, but the body has great difficulty in eliminating the dead bacterial carcasses. 

Best wishes, 

 David Scollard 

LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

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