Friday, September 9, 2016

(LML) International Leprosy Congress, Beijing, September 2016

Leprosy Mailing List – September 9,  2016

Ref.: (LML) International Leprosy Congress, Beijing, September 2016  

From:  Robert Jerskey, Carlsbad, California, USA


 

Dear Pieter,

 

 

Maybe this has already been brought to your attention by other LML readers:

 

Here (LML, September 8, 2016) Ben lists the session on “Clinical problems in leprosy” be held in room 201 CD, in the afternoon of September 18th, from 13.30-15.00 hours. However, in the ILA Programme that was sent by email to all attendees via a PDF file, it lists his session as occurring on Monday, the 19th  [same time frame, same room].

 

Has there been a change since that Programme was sent out several weeks ago, or is this an error which LML readers need to know?

 

Thank you any helpful clarification, and for your service, as always,

 

 

Robert

 


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 


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Thursday, September 8, 2016

(LML) International Leprosy Congress, Beijing, 2016

Leprosy Mailing List – September 8,  2016

Ref.: (LML) International Leprosy Congress, Beijing, 2016  

From:  Ben Naafs, Munnekesburen, the Netherlands


 

Dear Colleagues,

 

The International Leprosy Congress in Beijing is coming near and so the session on:  “Clinical problems in leprosy”.  This session will be held in room 201 CD, in the afternoon of September 18th, from 13.30-15.00 hours.

 

The objective is to discuss clinical problems: it is purely a session to exchange ideas and experiences, and to try to answer each other questions. Everybody is invited to attend. It is hoped for, and expected, that the cumulative knowledge will be able to solve most problems. Answers may not always be evidence based, but will be backed by experience.

 

The discussions will be led by Professor Rao PN and me, but there will be no speaker or group of experts to answer the questions.  Professor Karr HK has offered to attend and share his experience as many other LML readers did. All of us are the “experts”.

 

By this LML message we invite not only the clinicians but also the researchers. Because their knowledge is needed to give an answer to the clinical questions and maybe we can give an answer to their questions.

 

Let us make a success of the congress and this session!

 

Some questions raised so far:

-          How to diagnose leprosy, do we need to revise the cardinal signs?

-          Is there an alternative for counting of the lesions? Do we include involved nerves?

-          How do we teach people to differentiate leprosy from other diseases?

-          What do we do with skin smears, can it be done at primary level? Are there alternatives?

-          When does leprosy have to be treated or retreated?

-          How to differentiate relapse from reaction?

-          How treat, evidence based, a reaction in children?

-          How to detect silent nerve damage?

-          What is happening during silent nerve damage?

-          How to treat highly multibacillary patients with impaired liver function?

-          Are there clinical predictive symptoms for the risk of new or further nerve damage?

-          When do we do nerve surgery?

There are most likely more questions. Ask them at the meeting (or send beforehand to LML)!

 

I would like to quote Grace Warren: “Where one does not think about, one never sees”. “What one does not recognize one will never diagnose”.

 

A summary of the meeting will be published in LML.

 

Welcome,

 

Ben


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com


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Wednesday, September 7, 2016

(LML) New publications on leprosy and related issues - September 2016leprosy

 



Leprosy Mailing List – September 7,  2016

Ref.:  (LML) New publications on leprosy and related issues – September 2016leprosy and related issues – September 2016ublications on leprosy and

From:  Jiske Erlings, Amsterdam, the Netherlands


 

Dear Pieter,

 

Greetings from Infolep!

The new Infolep portal is now live. Please take a look at
www.leprosy-information.org and let me know what you think. Below you will find a selection of recent publications on leprosy. Feel free to contact me to receive the full text versions if a link to the full text is not included. And keep sending us your publications on leprosy or material on leprosy in your language to include in the portal.

If you are at the ILC in Beijing, please come say hello at the joint ILEP exhibition stand which you will find at the BICC level 2.

With kind regards,
 
Jiske Erlings
INFOLEP Information specialist

infolep@leprastichting.nl
 

 

 

Highlighted publication

 

 

Global leprosy update, 2015: Time for action, accountability and inclusion. Situation de la lèpre dans le monde, 2015: l'heure est à l'action, à la responsabilisation et à l'inclusion.
Wkly Epidemiol Rec. 2016 Sep 2;91(35):405-420.
Download PDF

 

 

New publications

 

 

Molecular evidence for the aerial route of infection of Mycobacterium leprae and the role of asymptomatic carriers in the persistence of leprosy.
Araujo S, Freitas LO, Goulart LR, et al. Clin Infect Dis. 2016
Read abstract


Diagnosis and medical treatment of neuropathic pain in leprosy.
Arco RD, Nardi SM, Bassi TG, et al. Rev Lat Am Enfermagem.
2016 Aug 8;24:e2731.
Download PDF


Transmission of drug-resistant leprosy in Guinea-Conakry detected by molecular epidemiological approaches.
Avanzi C, Busso P, Benjak A, et al. Clin Infect Dis. 2016 Aug 23.
Read abstract 


The value of histopathological diagnosis in the elderly patients with granulomatous dermatoses.
Badea MA, Buicu CF, Sin AI, et al. Rom J Morphol Embryol. 2016;57(2):525-9.
Read abstract


DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum.
Dias AA, Silva CO, Santos JP, et al. J Immunol.
2016 Jul 29.
Read abstract 


Leprosy Masquerading as Systemic Rheumatic Diseases.
El-Gendy H, El-Gohary RM, Shohdy KS, et al. J Clin Rheumatol. 2016 Aug;22(5):264-71
Read abstract


Evidences of aerial route of Mycobacterium leprae infection and doubts about transmission and natural protection in leprosy.
Frade MA, Foss NT. Clin Infect Dis. 2016 Aug 23.
Read abstract


Application of Mycobacterium Leprae-specific cellular and serological tests for the differential diagnosis of leprosy from confounding dermatoses.
Freitas AA, Hungria EM, Costa MB, et al. Diagn Microbiol Infect Dis. 2016 Jul 27.
Read abstract


Addition of Mycobacterium indicus pranii (MIP) vaccine as an immunotherapeutic with standard chemotherapy in borderline leprosy: A double blind study to assess clinical improvement (A preliminary report).
Kamal R, Pathak V, Kumari A, et al. Br J Dermatol. 2016 Aug 12.
Read abstract 


Jagged1 Instructs Macrophage Differentiation in Leprosy.
Kibbie J, Teles RM, Wang Z, et al. PLoS Pathog. 2016 Aug 17;12(8):e1005808.
Download PDF


Lucio Phenomenon In Non-endemic Area of Northeast Asia.
Kim JY, Chung KY, Kim WJ, et al. J Eur Acad Dermatol Venereol. 2016 Aug 18.
Read abstract 


Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae.
Medeiros RC, Vasconcelos KG, Cardoso FK, et al. J Biol Chem. 2016 Aug 23.
Download PDF


Profiling of Intracellular Metabolites: An Approach to Understanding the Characteristic Physiology of Mycobacterium leprae.
Miyamoto Y, Mukai T, Matsuoka M, et al. PLoS Negl Trop Dis. 2016 Aug 1;10(8):e0004881.
Download PDF


Drug-resistance in leprosy: moving toward understanding the scope of the problem and how to tackle it.
Moraes MO. Clin Infect Dis. 2016 Aug 23.
Read abstract 


Minocycline in leprosy patients with recent onset clinical nerve function impairment.
Narang T, Arshdeep, Dogra S. Dermatol Ther. 2016 Aug 23.
Read abstract


Schwann cells are vulnerable to primary infection by pathogens responsible for inflammatory peripheral nerve neuropathies; a brief review.
Neal JW, Gasque P. J Infect. 2016 Aug 18.
Read abstract


Spatial and temporal epidemiology of Mycobacterium leprae infection among leprosy patients and household contacts of an endemic region in Southeast Brazil.
Nicchio MV, Araujo S, Martins LC, et al. Acta Trop. 2016 Jul 25;163:38-45.
Read abstract


Leprosy: ancient disease remains a public health problem nowadays.
Noriega LF, Chiacchio ND, Noriega AF, et al. An Bras Dermatol. 2016 Jul-Aug;91(4):547-548.
Download PDF


Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature.
Ozturk Z, Tatliparmak A. Dermatol Ther. 2016 Aug 23.
Read abstract 


Mycobacterium leprae Activates Toll-Like Receptor-4 Signaling and Expression on Macrophages Depending on Previous Bacillus Calmette-Guerin Vaccination.
Polycarpou A, Holland MJ, Karageorgiou I, et al. Front Cell Infect Microbiol.
2016 Jul 8;6:72.
Download PDF


A Case of Fluoroquinolone-Resistant Leprosy Discovered after 9 Years of Misdiagnosis.
Raharolahy O, Ramarozatovo LS, Ranaivo IM, et al. Case Rep Infect Dis. 2016;2016:4632369.
Download PDF


A case of leprosy in Malawi. Making the final push towards eradication: a clinical and public health perspective.
Roe C, May LS. Infect Dis Poverty. 2016 Sep 2;5(1):90.
Downloand PDF


Renal amyloidosis in leprosy, an infrequent cause of nephrotic syndrome in Europe.
Sanz-Martín N, Samillán-Sosa Kdel R, De Miguel J, et al. BMJ Case Rep. 2016 Aug 3;2016.
Read abstract 


Proposing a Compartmental Model for Leprosy and Parameterizing Using Regional Incidence in Brazil.
Smith RL. PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004925.
Download PDF


Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum.
Schmitz V, Prata RB, Barbosa MG, et al. PLoS Negl Trop Dis. 2016 Aug 24;10(8):e0004955.
Download PDF


Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy.
Sun Y, Irwanto A, Toyo-Oka L, Hong M, et al.
Sci Rep. 2016 Aug 10;6:31429.
Download PDF


Presence of viable Mycobacterium leprae in environmental specimens around houses of leprosy patients.
Turankar RP, Lavania M, Singh M, et al. Indian J Med Microbiol.
2016 Jul-Sep;34(3):315-21.
Download PDF


Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China.
Wang D, Li GD, Zhang DF, et al. Infect Genet Evol. 2016 Aug 20.
Read abstract


Quality of life in patients with erythema nodosum leprosum in Kuala Lumpur, Malaysia.
Yap FB, Kiung ST, Yap JB. Indian Dermatol Online J. 2016 Jul-Aug;7(4):255-8.
Download PDF


 

 

Journals & Newsletters

 

 

Community Eye Health Journal: http://www.cehjournal.org/

Disability, CBR & Inclusive Development:
http://dcidj.org/

Hansenologia Internationalis:
http://www.ilsl.br/revista/atual.php
 
Leprosy Review:
https://www.lepra.org.uk/Pages/FAQs/Category/volume-87

Plos Neglegted Tropical Diseases:
http://journals.plos.org/plosntds/
 
Revista de Leprología:
http://www.leprosy-information.org/resource/revista-de-leprologia
 
WHO Goodwill Ambassador’s Newsletter for the elimination of leprosy:
http://www.leprosy-information.org/resource/who-goodwill-ambassador-s-newsletter-elimination-leprosy
 

 

 

Websites & Services

 

 

InfoNTD - Information on cross-cutting issues in Neglected Tropical Diseases (NTDs) https://www.infontd.org/

LML - Leprosy Mailing List a free moderated email list that allows all persons interested in this theme to share ideas, information, experiences and questions.
http://leprosymailinglist.blogspot.nl/
 
The new International Leprosy Association – History of Leprosy
http://leprosyhistory.org/ website.


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com


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Sunday, September 4, 2016

(LML) NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

Leprosy Mailing List – September 4,  2016

Ref.:    (LML)  NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

From: José Antonio Garbino, Bauru, Brazil


Dear Pieter

 

Wim Theuvebnet asked me (LML, August 30, 2016) that when a significant nerve function loss was found, what was the subsequent plan of action? Was any nerve decompression done to restore function and if so, what were the results?

If we see demyelination with small amount of axonal loss we use to treat with steroid, if it doesn´t improve as was our expectation it goes to nerve decompression. With nerve conduction, we can show if the treatment is available or not. If we see pronounced axonal lesion, the prognosis is pour and treatment may be innocuous.

 

But I have a question to you also. When do you extend the tibial decompression to distal portion, that is, to lateral plantar nerve in the middle foot?

 

 

Best regards,

 

Garbino 

José Antonio Garbino, MD, PhD – Clinical Neurophysiology /ILSL

Co-ordinator  of the Clinical Neurophysiology Post-graduation Program


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 


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(LML) NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

Leprosy Mailing List – September 4,  2016

Ref.:   (LML)  NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

From: Ben Naafs, Munnekesburen, the Netherlands


 

Beste Pieter,

Dr. Garbino's article is excellent in describing lesion levels along the tibial nerve (LML, September 1, 2016). I enjoyed it too and it reminded me a retrospective study together with Van Droogenbroeck. In this study we showed the effect on the healing of the ulcers and a protective effect against new ones (J.B.A. Van Droogenbroeck et B. Naafs. Neurolyse et arteriolyse du nerf tibial postérieur dans la lèpre: Etude comparati¬ve de leur action dans les ulceres plantaries atones. Méd. Trop. 37 (1977) 777-779).

With regards,

Ben


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com


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Thursday, September 1, 2016

(LML) NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

Leprosy Mailing List – September 1,  2016

Ref.:   (LML)  NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

From: James Wilton, Portland, USA


Dear Pieter,

Dr. Garbino's article is excellent in describing lesion levels along the tibial nerve. I have been performing tibial nerve decompression neurolysis surgery on Hansen patients for the past 14 years in Ecuador. Postoperatively we have demonstrated on electro-diagnostic testing return of sensation and return of motor power in over 50% of the patients that we operate on. We also have identified a more proximal site of compression at the Soleal Sling interproximal posterior lower leg and decompress this area routinely with these patients.

Dr. James Wilton

 


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 


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(LML) NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

Leprosy Mailing List – August 30,  2016

Ref.:    (LML)  NERVE CONDUCTION STUDIES OF THE TIBIAL NERVE ACROSS THE TARSAL TUNNEL IN LEPROSY PATIENTS

From: Wim Theuvenet, Apeldoorn, the Netherlands

 


 

 

Dear Pieter,

 

I would like to thank Dr. Garbino for sharing his very interesting article and the results of the research done at ILSL (LML, August 30, 2016). It increases our knowledge of the peripheral neuropathy of the lower limbs in leprosy, and may help us to prevent function loss and foot ulceration.

 

I have a question. When a significant nerve function loss was found, what was the subsequent plan of action? Was any nerve decompression done to restore function and if so, what were the results?

 

With kind regards,  

 

 

Willem Theuvenet

 


LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

 


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