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Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.
Zoni A, Saboyá-Díaz M, Castellanos L, et al.. PLoS neglected tropical diseases. 2019; 13(2):e0007125.
Abstract Yaws is targeted for eradication by 2020 in the WHA66.12 resolution of the World Health Assembly. The objective of this study was to describe the occurrence of yaws in the Americas and to contribute to the compilation of evidence based on published data to undertake the certification of yaws eradication.
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Implementation science and stigma reduction interventions in low- and middle-income countries: a systematic review.
Kemp CG, Jarrett BA, Kwon C-, et al.. BMC medicine. 2019; 17(1):6.
Abstract Interventions to alleviate stigma are demonstrating effectiveness across a range of conditions, though few move beyond the pilot phase, especially in low- and middle-income countries (LMICs). Implementation science offers tools to study complex interventions, understand barriers to implementation, and generate evidence of affordability, scalability, and sustainability. Such evidence could be used to convince policy-makers and donors to invest in implementation. However, the utility of implementation research depends on its rigor and replicability. Our objectives were to systematically review implementation studies of health-related stigma reduction interventions in LMICs and critically assess the reporting of implementation outcomes and intervention descriptions.
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Men and Boys in Sanitation
Cavill S, Mott J, Tyndale-Biscoe P, et al.. Brighton: CLTS Knowledge Hub, Institute of Development Studies, University of Sussex
Abstract Discussions of gender in sanitation and hygiene (S&H) often focus on the roles, positions or impacts on women and girls, who bear the greatest burden of work related to water, sanitation and hygiene (WASH). Efforts to improve S&H and change social norms do not always actively engage men and boys in the most effective or transformative way. We must learn more about the roles men and boys actually play now and – if necessary – how they can be modified to make efforts more successful. This Learning Brief outlines the findings of a review that focused on men and boys: the problems they cause and experience, how to engage them (or not), and how to mobilise them as allies in the transformation of sanitation and hygiene outcomes.
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Burden of Chagas disease in Brazil, 1990-2016: findings from the Global Burden of Disease Study 2016.
Martins-Melo FR, Carneiro M, Ribeiro ALP, et al.. Int. J. Parasitol. 2019.
Abstract Chagas disease continues to be an important cause of morbidity, mortality and disability in several Latin American countries including Brazil. Using findings from the Global Burden of Disease Study 2016 (GBD 2016), we present years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) due to Chagas disease in Brazil, by gender, age group, and Brazilian states, from 1990 to 2016.
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Out of the silos: identifying cross-cutting features of health-related stigma to advance measurement and intervention.
Van Brakel WH, Cataldo J, Grover S, et al.. BMC medicine. 2019; 17(1):13.
Abstract Many health conditions perceived to be contagious, dangerous or incurable, or resulting in clearly visible signs, share a common attribute - an association with stigma and discrimination. While the etiology of stigma may differ between conditions and, sometimes, cultural settings, the manifestations and psychosocial consequences of stigma and discrimination are remarkably similar. However, the vast majority of studies measuring stigma or addressing stigma through interventions employ a disease-specific approach.
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A systematic review of multi-level stigma interventions: state of the science and future directions.
Rao D, Elshafei A, Nguyen M, Hatzenbuehler ML, Frey S, Go VF. BMC medicine. 2019; 17(1):41.
Abstract Researchers have long recognized that stigma is a global, multi-level phenomenon requiring intervention approaches that target multiple levels including individual, interpersonal, community, and structural levels. While existing interventions have produced modest reductions in stigma, their full reach and impact remain limited by a nearly exclusive focus targeting only one level of analysis.
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Neglected tropical diseases in Europe: rare diseases and orphan drugs?
Calleri G, Angheben A, Albonico M. Infection. 2019; 47(1):3-5.
Abstract Neglected tropical diseases are becoming more and more frequent in Europe due to the increasing immigration from endemic areas. Nonetheless specific treatments are scarcely available in many European countries, since they are neither officially licensed nor marketed. Only a few referral health centres can afford to access drugs for NTDs due to complex bureaucracy and high cost, importing or providing them via the WHO. Health professionals and institutions in this domain should solicit other stakeholders (such as NGOs, the civil society, scientific societies) to sensitize health authorities to improve access to treatment for such debilitating diseases.
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Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar.
Dunn JC, Bettis AA, Wyine N, et al.. PLoS neglected tropical diseases. 2019; 13(2):e0006591.
Abstract Mass drug administration (MDA), targeted at school-aged children (SAC) is the method recommended by the World Health Organization for the control of morbidity induced by soil-transmitted helminth (STH) infection in endemic countries. However, MDA does not prevent reinfection between treatment rounds and research suggests that only treating SAC will not be sufficient to bring prevalence to low levels and possibly interrupt transmission of STH. In countries with endemic infection, such as Myanmar, the coverage, who is targeted, and rates of reinfection will determine how effective MDA is in suppressing transmission in the long-term.
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Gender equity in mass drug administration for neglected tropical diseases: data from 16 countries.
Cohn DA, Kelly MP, Bhandari K, et al.. International health. 2019.
Abstract Gender equity in global health is a target of the Sustainable Development Goals and a requirement of just societies. Substantial progress has been made towards control and elimination of Neglected Tropical Diseases (NTDs) via mass drug administration (MDA). However, little is known about whether MDA coverage is equitable. This study assesses the availability of gender-disaggregated data and whether systematic gender differences in MDA coverage exist.
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Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates.
Bailey F, Mondragon-Shem K, Haines LR, et al.. PLoS Negl Trop Dis. 2019; 13(2):e0007092.
Abstract Major depressive disorder (MDD) associated with chronic neglected tropical diseases (NTDs) has been identified as a significant and overlooked contributor to overall disease burden. Cutaneous leishmaniasis (CL) is one of the most prevalent and stigmatising NTDs, with an incidence of around 1 million new cases of active CL infection annually. However, the characteristic residual scarring (inactive CL) following almost all cases of active CL has only recently been recognised as part of the CL disease spectrum due to its lasting psychosocial impact.
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Results of a national school-based deworming programme on soil-transmitted helminths infections and schistosomiasis in Kenya: 2012-2017.
Mwandawiro C, Okoyo C, Kihara J, et al. Parasit Vectors. 2019; 12(1):76.
Abstract Soil-transmitted helminth (STH) and schistosome infections are among the most prevalent neglected tropical diseases (NTDs) in the world. School-aged children are particularly vulnerable to these chronic infections that can impair growth, nutritional status and cognitive ability. In 2012, Kenya began a national school-based deworming programme (NSBDP) aimed at reducing infection and associated morbidity. Here, we present the changes in STH and schistosome infections between baseline and endline assessments, as well as explore the yearly patterns of infection reductions.
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A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries.
Kane JC, Elafros MA, Murray SM, et al.. BMC medicine. 2019; 17(1):17.
Abstract Stigma is associated with health conditions that drive disease burden in low- and middle-income countries (LMICs), including HIV, tuberculosis, mental health problems, epilepsy, and substance use disorders. However, the literature discussing the relationship between stigma and health outcomes is largely fragmented within disease-specific siloes, thus limiting the identification of common moderators or mechanisms through which stigma potentiates adverse health outcomes as well as the development of broadly relevant stigma mitigation interventions.
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Buruli Ulcer: a review of the current knowledge.
YOTSU RR, Suzuki K, Simmonds RE, et al.. Current tropical medicine reports. 2018.
Purpose of the Review Buruli ulcer (BU) is a necrotizing and disabling cutaneous disease caused by , one of the skin-related neglected tropical diseases (skin NTDs). This article aims to review the current knowledge of this disease and challenges ahead.
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The Global Burden of Disease of Zoonotic Parasitic Diseases: Top 5 Contenders for Priority Consideration.
Pisarski K. Tropical medicine and infectious disease. 2019; 4(1).
Abstract This review considers the available literature and the attribution of burden of disease to the most insidious NTDs and recommends which five are deserving of policy prioritisation. In line with WHO analyses of NTDs, intestinal nematode infections, leishmaniasis, schistosomiasis, and lymphatic filariasis should be prioritised, as well as the burden of disease of cryptosporidiosis, which is largely underestimated. Both monitoring and treatment/prevention control methods for cryptosporidiosis are suggested and explored.
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