Leprosy Mailing List – November 15, 2022
Ref.: (LML) Novel approaches in the treatment of Hansen's disease in the US
From: Barbara Stryjewska, Baton Rouge, USA
Dear Pieter,
I would like to share with the LML readers , the latest publication regarding RMM treatment as a pre-print.
Novel approaches in the treatment of Hansen's disease (Leprosy): a case series
of multidrug therapy of monthly rifampin, moxifloxacin, and minocycline (RMM) in the
United States. Carlos Franco-Paredes, Elizabeth Garcia-Creighton, Andrés Henao-Martinez, et al. Ther Adv Infect Dis 2022, Vol. 9: 1–10 DOI: 10.1177/ 20499361221135885
Abstract: The World Health Organization (WHO) recommends multidrug therapy (MDT) for the treatment of paucibacillary and multibacillary forms of leprosy, also known as Hansen's disease (HD). MDT combinations of dapsone, rifampin, and clofazimine have reduced the prevalence of the disease but are not without adverse effects impacting regimen adherence. Hence, an urgent need exists to consider alternative MDT regimens with an improved safety profile that promotes treatment adherence. Herein, we described a case series of 10 patients with HD (nine patients with multibacillary leprosy and one with pure neural leprosy) treated with monthly rifampin, moxifloxacin, and minocycline (RMM). Etc., etc.
Sincerely,
Barbara M. Stryjewska, M. D.
Chief Medical Officer
Principal Investigator
Clofazimine IND # 67,033
National Hansen's Disease Program
HSB/HRSA/HHS
9181 Interline Ave
Baton Rouge, LA 70809
Ph #: (225) 756-3700
Fax # (225) 756-3706
NHDP Web Site: http://www.hrsa.gov/hansens-disease/
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << editorlml@gmail.com
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