Leprosy Mailing List – March 19, 2020
Ref.: (LML) the Maltalep study- Harm after SDR prophylaxis
From: Diana Lockwood, Barbara de Barros and Steve Walker, London
Dear Pieter,
We discussed the increase in MB leprosy cases that occurred in a trial of single dose Rifampicin (SDR) and BCG, the MALTALEP trial on the LML in Oct 2019. This trial shows no significant protection against leprosy by SDR.
We have now published our comments as a letter in International Journal of Infectious Diseases 2020. We attach the link to the paper. https://doi.org/10.1016/j.ijid.2020.01.054
Since there is now evidence of harm in giving SDR as prophylaxis against leprosy we suggest that there should be further discussions about the use of this intervention.
Diana Lockwood
Barbara de Barros
Steve Walker
Clinical Research Department, London School of Hygiene & Tropical Medicine, London UK
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << editorlml@gmail.com
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