Leprosy Mailing List – March 19, 2020
Ref.: (LML) the Maltalep study- Harm after SDR prophylaxis
From: Annemiek Geluk, Leiden, the Netherlands
Dear Pieter,
In the International Journal of Infectious Diseases (IJID) we have previously replied to the Letter to the Editor by Diana Lockwood, Barbara de Barros and Steve Walker (see attached)
The MALTALEP trial conducted in Bangladesh investigated the possibility to increase the protective effect of BCG (re)-vaccination among contacts with SDR. This combined intervention makes it unsuitable to directly compare with the results of the COLEP trial that was conducted over 10 years ago and studied the protective effect of SDR only. We have explained that in our reply to the editor of IJID.
The conclusion of Lockwood et al. about the harmful effect of SDR in general cannot be based on the results of the MALTALEP trial.
Kind regards,
Prof. dr. A. Geluk – Dept. Infectious Disease – LUMC
Immunodiagnostics of Leprosy & Tuberculosis
https://www.universiteitleiden.nl/medewerkers/annemieke-geluk
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << editorlml@gmail.com
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