Leprosy Mailing List – July 27, 2026
Ref.: (LML) LAMP: a breakthrough
From: Joel Almeida, Mumbai, the Netherlands
____________________________________________________________________________
Dear Pieter and colleagues,
LAMP was invented in 2000. (1) It can be used for a wide range of pathogens (not just M. leprae or M. lepromatosis or leishmania etc (2) but the whole range of viral or bacterial or parasitic or other pathogens). Nasal swabs have the advantage of being relatively non-invasive. They also allow the simultaneous detection of a range of viral and other pathogens if needed.
In Hansen Disease (HD), the detection of asymptomatic cryptic LL is particularly important.
Many labs in endemic countries have been developing locally relevant versions. In India, the ICMR National Institute of Pathology, the ICMR JALMA Institute, the PGI medical and research institute (Chandigarh) and others are known to have their own versions. Technology institutes such as the IITs have developed low-cost supporting technology. Also labs in Brazil, China and elsewhere.
There is no need for HD to lag behind other diseases in the use of such user-friendly field technology. Partnership with a university / medical institute / lab will enable organizations of persons with lived experience to lead the charge against the bacillus.
Such technological breakthroughs keep shrinking the room for pessimism. The prospects of rapid progress grow.
With all sincerity,
Joel Almeida
References
1. T Notomi, H Okayama, H Masubuchi, T Yonekawa, K Watanabe, N Amino, T Hase. Loop-mediated isothermal amplification of DNA Nucleic Acids Res 2000 Jun 15;28(12):E63. doi: 10.1093/nar/28.12.e63.
2. Joshi, S.; Dixit, K.K.; Sharma, V.; Ramesh, V.; Singh, R.; Salotra, P. Rapid Multiplex Loop-Mediated Isothermal Amplification (m-LAMP) Assay for Differential Diagnosis of Leprosy and Post–Kala-Azar Dermal Leishmaniasis. Am. J. Trop. Med. Hyg. 2021, 104, 2085–2090.
____________________________________________________________________________
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << edit...@gmail.com
You received this message because you are subscribed to the Google Groups "Leprosy Mailing List" group.
To unsubscribe from this group and stop receiving emails from it, send an email to leprosymailinglist+unsubscribe@googlegroups.com.
To view this discussion visit https://groups.google.com/d/msgid/leprosymailinglist/d19d123f-eecb-43da-920f-23a16e7ac6a9n%40googlegroups.com.
No comments:
Post a Comment