(LML) ILEP Learning Guides

Leprosy Mailing List – May 8,  2018

Ref.:    (LML) ILEP Learning Guides

From:  Paul Saunderson, Alesund, Norway

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Dear Pieter,

I'm writing about the ILEP Learning Guides, written in 2000 or 2001, with titles such as "How to diagnose and treat leprosy", "How to recognise and manage leprosy reactions", etc.  They are still freely available online at <https://www.ilepfederation.org/about-leprosy/publications/>

Users are also free to print hard copies, if these are needed.  Originally, there were CDs with HD graphics for printing, but these are no longer available.

I have two questions for LML readers:

1. Does anyone still have the old HD CDs from which reprints can be made?  Some programs would like to have access to these, and I'm sure the files would be easy to transfer now, even though they were too big to email in 2001!

2. Do other programs still use the printed versions of the ILEP Learning Guides, and if so, is there interest having higher quality graphics made available, to improve the quality of the printing, perhaps with some editing of the text also?

 

With kind regards,

Paul Saunderson

<psaunderson@leprosy.org>

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

(LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy

Leprosy Mailing List – May 7,  2018

Ref.:    (LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy

From:  Arry Pongtiku, Papua, Indonesia

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Dear Pieter,

 

An interesting discussion in LML to differentiate between diabetic neuropathy and pure neurotic leprosy neuropathy.

 

I would like to say that both diabetes and leprosy without complication need simple instructions like self care (put feet in the water, clean, rub with vegetable/ coconut or hand body for overcoming dry skin/cracks). But also, simple exercises to improve blood circulation, strengthen muscles and to keep joints mobile to prevent complications. In some places both types of patients take part in Self Care Groups. In attached file find feet exercise video (in Bahasa Indonesia); it may be useful.

 

Thank you very much.

 

Salam,

 

Arry Pongtiku

Papua - Indonesia

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

(LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy

Leprosy Mailing List – May 4, 2018

Ref.:   (LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy

From:  James Wilson, New Hampshire, USA

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Dear Pieter,

 

Interesting ongoing conversation. I have been decompressing nerves as a student of doctor Dellon for the past 16 years in Ecuador and in the USA. I run a surgical team that performs peripheral nerve surgery on upper and lower extremity nerves in Hansen's patients in South America. Our results have been excellent in long-term follow-up for return of motor function, decreased limb pain and increased sensation.

 

The Hansen nerves do not have amyloid deposition such as what we see in the diabetic patient however they are quite swollen and show obvious signs of impingement at the fibro-osseous tunnels at the joint levels where these nerves are decompressed in both upper and lower extremities.

 

Interestingly we have had some patients with diabetes and Hansen's Disease which creates a real double crush type syndrome on the nerve.

 

Sincerely,

 

Dr. James Wilton

Valley Regional Hospital Claremont, New Hampshire, USA 

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

(LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy

Leprosy Mailing List – May 3,  2018

Ref.:    (LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy

From:  Pieter AM Schreuder, Maastricht, the Netherlands

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Dear colleagues,

 

 

In his LML message of April 22, 2018, Eric Slim stated that "Nerve enlargement can also be seen in diabetes related neuropathy but structural differences between diabetes and leprosy nerve impairment can be seen on ultrasound".  He also writes when Salvatore Noto questioned him about this statement: "that I was referring to the work of dr Dellon, who's surgical treatment consists of decompression of the nerve, based on the hypothesis of increased water content in the nerve resulting in subperineurial and endoneurial edema. An example for this hypothesis is papilopathy of the eye, occuring in diabetes, also caused by axonal edema."

 

Differential diagnosis of enlarged peripheral nerve (by Michael Donaghy Department of Clinical Neurology, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK. Practical Neurology, 2003, 3, 40–45):
- Leprosy,
- Hereditary motor and sensory neuropathy,
- Neurofibromatosis,
- Refsum's disease,
- Perineuroma/localized hypertrophic neuropathy,
- Nerve tumours
- Amyloidosis

Diabetes is not mentioned.

 

When asking Wim Theuvenet about Eric"s statement, he writes: "I agree with Dr. Eric Slim that also in diabetes the nerves are often found to be enlarged, this in 30 to 60 % of the cases and depending on the screening technique used. This is the basis for the nerve decompressions described in the Ph.D. thesis (Utrecht March 6, 2007 Surgical approach to lower extremity nerve decompression in the patient with diabetic neuropathy) of Prof Lee Dellon. In general, the swelling is more diffuse and less tender than in leprosy. Indeed the D.D. on the basis of nerve enlargement can be difficult!

 

In the first place they do not refer to (peripheral nerves of) the hand/arm. In the second place they do not mention hardening of the nerves. In the third place are these edematous nerves palpable enlarged or only as seen by ultrasound? In the fourth place are the lateral popliteal and sural nerves involved in diabetes?

 

Very interesting topic indeed. Welcome to the discussion.

 

 

Pieter AM Schreuder

 

 

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

(LML) Infolep update on new leprosy publications – May 2018

Leprosy Mailing List – May 1,  2018

Ref.:  (LML) Infolep update on new leprosy publications – May 2018 

From:  Jiske Erlings, Amsterdam, the Netherlands

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Dear colleagues,  Below you will find another overview of new publications on leprosy and related subjects. Did you know that the Infolep portal gives you access to over 27,750 publications on leprosy? Feel free to contact me to receive the full text versions if a link to the full text is not included or for assistance with your literature research. You are also invited to send us your publications on leprosy or material on leprosy in your language for inclusion in the portal. For more information about Infolep leprosy information services & portal please watch this short video produced for us by The Coalition for Operational Research on Neglected Tropical Diseases (COR-NTD). With warm regards, Jiske Erlings, j.erlings@leprastichting.nl Infolep Information officer     Share   Tweet   Forward     Highlighted publications     Chemoprophylaxis of leprosy with rifampicin in contacts of multibacillary patients: study protocol for a randomized controlled trial. Dos Santos DS, Duppre NC, Sarno EN, et al. Trials. 2018 Apr 23;19(1):244. Download PDF LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection. Duthie MS, Pena MT, Ebenezer GJ, et al. NPJ Vaccines. 2018 Mar 28;3:12. Download PDF       New publications     Testicular atrophy and its clinical manifestations in a patient released from leprosy treatment. Achdiat PA, Fadilla Y, Gunawan H, et al. Lepr Rev. 2018; 89(1):83-86. Download PDF   Genetic variants, structural, and functional changes of Myelin Protein Zero and Mannose-Binding Lectin 2 protein involved in immune response and its allelic transmission in families of patients with leprosy in Colombia. Cardona-Pemberthy V, Rendón M, Beltrán JC, et al. Infect. Genet. Evol. 2018; 61:215-223. Read abstract   Effect of Brazil's Conditional Cash Transfer Programme on the new case detection rate of leprosy in children under 15 years old. De Andrade KVF, Nery JS, Penna MLF, et al. Lepr Rev. 2018; 89(1):13-24. Download PDF   Chemoprophylaxis of leprosy with rifampicin in contacts of multibacillary patients: study protocol for a randomized controlled trial. Dos Santos DS, Duppre NC, Sarno EN, et al. Trials. 2018 Apr 23;19(1):244. Download PDF   Can anti-PGL-1 and anti-NDO-LID-1 antibody titers be used to predict the risk of reactions in leprosy patients? Devides AC, Rosa PS, de Faria Fernandes Belone A, et al. Diagn. Microbiol. Infect. Dis. 2018. Read abstract   LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection. Duthie MS, Pena MT, Ebenezer GJ, et al. NPJ Vaccines. 2018 Mar 28;3:12. Download PDF   Implementing the Global Leprosy Strategy 2016–2020 in Nepal: lessons learnt from active case detection campaigns. Gillini L, Cooreman E, Pandey B, et al. Lepr Rev. 2018; 89(1):77-82. Download PDF   Mycobacterium leprae- specific antibodies in multibacillary leprosy patients decrease during and after treatment with either the regular 12 doses multi-drug therapy (MDT) or the uniform 6 doses MDT. Hungria EM, Bührer-Sékula S, Oliveira RM, et al. Front Immunol. 2018. Read abstract   A case-control study comparing the Dermatology Life Quality Index (DLQI) ratings of patients undergoing leprosy treatment, people cured of leprosy, and controls in Vietnam. Hunt WTNH, Hùng NT, Tru'ò'ng NN, et al. Lepr Rev. 2018; 89(1):46-55. Download PDF   Ulnar and superficial radial nerve swellings in two patients with leprosy. Kumar N, Garg RK, Malhotra HS. Am. J. Trop. Med. Hyg. 2018; 98(4):939-940. Download PDF   Incidence of leprosy in Firozabad district (Uttar Pradesh). Kumar A, Girdhar A, Chakma JK. Indian J Dermatol Venereol Leprol. 2018. Download PDF   Leprosy and American cutaneous leishmaniasis coinfection. Mercadante LM, Santos MASD, Pegas ES, et al. An Bras Dermatol. 2018; 93(1):123-125. Download PDF   The differences in leprosy-related stigma between 30 sub-districts in Cirebon District, Indonesia. Michgelsen J, Peters RMH, Van Brakel WH, et al. Lepr Rev. 2018; 89(1):65-76. Download PDF   Knowledge of slum community toward leprosy: A cross-sectional survey from Karad urban block of Western Maharashtra, India. Mohite RV. Asian J Pharm Clin Res. 2018;11(3):357-360. Download PDF   Association of APOE polymorphisms with multibacillary leprosy. Morgado de Abreu MAM. Br J Dermatol. 2018 Apr;178(4):833-834. Read abstract   Empowerment of communities in the promotion of Prevention of Disability (POD) for persons affected by leprosy in Tanzania. Mwasuka G, Shaban Z, Rwamtoga B, et al. Lepr Rev. 2018; 89(1):36-45. Download PDF   Functional evaluation of the hand after ulnar claw correction in patients with leprosy. Neto BC, Fontana AP, Silva DC, et al. Lepr Rev. 2018; 89(1):25-35. Download PDF   Acanthamoeba sp.S-11 phagocytotic activity on mycobacterium leprae in different nutrient conditions. Paling S, Wahyuni R, Winarni D, et al. Afr J Infect Dis. 2018; 12(1 Suppl):44-48. Download PDF   Clinical spectrum and quality of life (QoL) in patients with chronic polyneuropathy: A cross-sectional study. Panduranga MS, Vibha D, Prasad K, et al. J Peripher Nerv Syst. 2018 Apr 23. Read abstract   Innate immune responses in leprosy. Pinheiro RO, Schmitz V, Silva BJA, et al. Front Immunol. 2018 Mar 28;9:518. Download PDF   The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy: A randomized control trial. Prakoeswa C, Natallya FR, Harnindya D, et al. J Dermatolog Treat. 2018:1-20. Read abstract   Factors associated with social participation of women affected with leprosy reporting at a referral centre in Chhattisgarh, India. Ramasamy S, Govindharaj P, Panneerselvam S, et al. Lepr Rev. 2018; 89(1):56-64. Download PDF   Current situation of leprosy in India and its future implications. Rao PN, Suneetha S. Indian Dermatol Online J. 2018 Mar-Apr;9(2):83-89. Download PDF   Why funding for neglected tropical diseases should be a global priority. Reed SL, McKerrow JH. Clin Infect Dis. 2018 Apr 24. Download PDF   BCG and adverse events in the context of leprosy. Richardus R, van Hooij A, van den Eeden SJF, et al. Front Immunol. 2018; 9:629. Download PDF   Minimal essential data to document contact tracing and single dose rifampicin (SDR) for leprosy control in routine settings: a practical guide. Richardus JH, Kasang C, Mieras L, et al. Lepr Rev. 2018; 89(1):2-12. Download PDF   Emerging concepts of adaptive immunity in leprosy. Sadhu S, Mitra DK. Front Immunol. 2018 Apr 9;9:604. Download PDF   Differential growth of Mycobacterium leprae strains (SNP genotypes) in armadillos. Sharma R, Singh P, Pena M, et al. Infect. Genet. Evol. 2018. Read abstract   Social determinants, their relationship with leprosy risk and temporal trends in a tri-border region in Latin America. Simionato de Assis I, Arcoverde MAM, Ramos ACV, et al. PLoS Negl Trop Dis. 2018; 12(4):e0006407. Download PDF   Mycobacterium lepromatosis lepromatous leprosy in US citizen who traveled to disease-endemic areas. Singh AV, Chauhan DS. Emerg Infect Dis. 2018 May;24(5):951-952. Download PDF   Autoimmunity to Tropomyosin-Specific Peptides Induced by in Leprosy Patients: Identification of Mimicking Proteins. Singh I, Yadav AR, Mohanty KK, et al. Front Immunol. 2018; 9:642. Download PDF   Nerve growth factor and pathogenesis of leprosy: review and update. Sousa JR, Aarão TS, Falcão AS, et al. Front Immunol. 2018. Read abstract   Type I interferons, autophagy and host metabolism in leprosy. Toledo-Pinto TG, Batista-Silva LR, Medeiros RCA, et al. Front Immunol. 2018; 9:11. Download PDF   Polyhexanide 0.2% in treatment of trophic foot ulcers in leprosy - preliminary study. Zanchin TN, Serafini CB, Brandão FS, et al. An Bras Dermatol. 2018; 93(1):145-147. Download PDF       Journals & Newsletters     Disability, CBR & Inclusive Development: http://dcidj.org/ Hansenologia Internationalis: http://www.ilsl.br/revista/atual.php Indian Journal of Leprosy: http://www.ijl.org.in/index.html  Leprosy Review: https://www.lepra.org.uk/Pages/FAQs/Category/volume-89 Leprosy Review Repository (1928-2001) : http://leprev.ilsl.br/arquivo.php Plos Neglected Tropical Diseases: http://journals.plos.org/plosntds/   Revista de Leprología: http://www.leprosy-information.org/resource/revista-de-leprologia   WHO Goodwill Ambassador's Newsletter for the elimination of leprosy: http://www.smhf.or.jp/e/ambassador/index.html       Websites & Services     WHO Global Leprosy Programme http://www.who.int/lep/en/ & http://www.searo.who.int/entity/global_leprosy_programme/en/ LML - Leprosy Mailing List - a free moderated email list that allows all persons interested in this theme to share ideas, information, experiences and questions. http://leprosymailinglist.blogspot.nl/ InfoNTD - Information on cross-cutting issues in Neglected Tropical Diseases (NTDs) https://www.infontd.org/

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com