Can drug used in leprosy (Clofazimine, Dapsone, Rifampicin and Prednisolone) cause hyponatraemia?

Leprosy Mailing List – August 29^th, 2010

Ref.: Can drug used in leprosy (Clofazimine, Dapsone, Rifampicin and Prednisolone) cause hyponatraemia?

From: Lysbeth Duncan, Peebles , Scotland , UK

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Dear Dr. Noto,

I refer to Mr Adamou Idi’s message dated LML Aug. 23^rd, 2010. Having used the four drugs listed without seeing any evidence of hyponatraemia, personally I am not aware of this being a problem.

I do know that Rifampicin reduces the efficacy of prednisolone by 50%, as can oral contraceptives. I shall forward this letter to a colleague who is a leprologist and Microbiologist in case he can help further.

Best regards,

Lysbeth Duncan

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1547305/pdf/bmjcred00545-0011.pdf

Rifampicin reduces effectiveness and bioavailability of prednisolone

w a c mcallister, p j thompson, s m al-habet, h j rogers

british medical journal volume 286 19 march 1983