Leprosy Mailing List – October 7th, 2010
Ref.: Clofazimine
From: H Joseph Kawuma, Jinja , Uganda
Dear Salvatore,
While the search for the original paper* continues, I would like to add some detail to my statement regarding "clinical evidence" (LML – Oct. 2nd, 2010). The tools: slit skin smears and histopathology were of course available to support the clinical diagnosis but they I suppose cannot be used as conclusive evidence of resistance to Clofazimine.
I wonder if there will be any "Yes" answer to Grace Warren's question in its new form. I am aware of a publication in the Indian Journal of leprosy by Ebenezer and others (2002) describing cases of primary and secondary clofazimine resistance from a series of biopsies before 1997. Again one would need to study the paper in order to obtain information about the patients.
Has the mode of action of clofazimine been fully understood now? Do we now have a reliable technique for testing Clofazimine resistance?
H Joseph Kawuma
*
Titia Warndorff-van Dieden, "Clofazimine-resistant leprosy, a case report" International journal of leprosy and other mycobacterial diseases, volume 50, number 2 June 1982."
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