Has clofazimine resistance seen to develop in a patient?

Leprosy Mailing List – September 29^th, 2010

Ref.:   Has clofazimine resistance seen to develop in a patient?

From: Grace  Warren, Sidney , Australia

---

 Dear Salvatore,

Another letter talking about clofazimine resistance (thank you to Dr Kar for his contribution dated LML Sept. 28^th, 2010).  I was using clofazimine for many years, including the original trials.  I have asked many time if any patient has ever been found to develop clofazimine resistance?  Yes I know that some resistant strains have been  developed in mice (I think it was mice) but clofazimine itself? 

Yes, I know it was over 10 years before dapsone resistance was proven and, that within 30 years we were finding incidence of over 50% on new cases had dapsone resistance in some countries.  Can anyone give me a definite answer:- has clofazimine resistance seen to develop in a patient?

Thank you 

Grace  Warren

Previously Adviser in Leprosy and Reconstructive Surgery  for the leprosy Mission in Asia(1975-94)