Leprosy Mailing List – May 5, 2015
Ref.: (LML) Parenteral treatment of leprosy reactions
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Dear Pieter,
I would like to draw the attention of Dr. Harun (LML, April 28, 2015) and that of the LML readers to a trial of high-dose intravenous methylprednisolone carried out by Walker and colleagues at Anandaban Leprosy Hospital in Nepal. This trial was published in PLoS NTD in 2011 (DOI: 10.1371/journal.pntd.0001041).
To our disappointment, the intravenous prednisolone did not have any dramatic beneficial effects, as seen in other conditions. In fact, the study highlighted the need for a longer steroid regimen in the treatment of leprosy reactions. This is currently being trialled in the so-called TENLEP trials; a large multi-country study led by Dr Erik Post, Royal Tropical Institute, Amsterdam.
With best wishes,
Wim van Brakel
Wim van Brakel, MD MSc PhD
Head Technical Department
Netherlands Leprosy Relief (NLR)
Email: w.v.brakel@leprastichting.nl
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << editorlml@gmail.com
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