Leprosy Mailing List – January 29, 2021
Ref.: (LML) clofazimine and QT prolongation
From: Ruth Butlin, London, UK
Dear Pieter,
I have heard that clofazimine can cause a significant degree of QT prolongation, especially when in combination with other drugs which have this propensity.
I wonder if this is only a significant clinical problem with high dose clofazimine (as used for ENL cases), not with the doses used in standard MDT?
How frequent is the problem in people who do not have a predisposing cardiac abnormality?
I wonder, should we consider taking ECGs before starting high dose clofazimine? This would be difficult to implement in many leprosy-endemic regions.
I would be grateful if anyone can point me to published evidence on this adverse effect of clofazimine. Thank you.
Yours faithfully,
C Ruth Butlin
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << editorlml@gmail.com
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