Stigmata in cutaneous leishmaniasis: Historical and new evidence-based concepts.
Al-Kamel MA. PLoS Negl Trop Dis. 2016; 10(12):e0005261.
Abstract The author highlights historical and current concepts of cutaneous leishmaniasis (CL) as a globally most prevalent and highly stigmatizing form of leishmaniasis disease, introduce new ideologies upon CL-related stigmata, review the most common determinants and implications of CL stigmata; and report a short survey illustrating stigmata experience among some affected patients from Yemen.
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Former Buruli ulcer patients' experiences and wishes may serve as a guide to further improve Buruli ulcer management.
Velink A, Woolley RJ, Phillips RO, Abass KM et al. PLoS Negl Trop Dis. 2016; 10(12):e0005261.
Abstract To get insight into patient perception of the management and control of Buruli ulcer a mixed methods research design was applied with a questionnaire and focus group discussions among former BU patients. Former patients positively evaluated both the effectiveness of the treatment and the financial contribution received for the travel costs to the hospitals. Pain experienced during treatment procedures, in particular wound care and the streptomycin injections, and the side-effects of the treatment were negatively evaluated.
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Neglected diseases: How intellectual property can incentivize new treatment.
Banthia V. Chicago-Kent Journal of Intellectual Property. 2016;16(1).
Abstract This paper addresses the imbalance in the development of treatments for neglected diseases. It analyzes the causes behind the imbalances, and the current legal and societal initiatives that are in place to address the diseases. In particular, the paper suggests that the current patent system fails to effectively incentivize the development of treatment for neglected diseases.
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Towards control of Chagas disease: the contribution of the new Brazilian consensus.
Ramos AN, Dias JCP, Correia D. Rev Soc Bras Med Trop. 2016; 49 Suppl 1:1-2.
Abstract On behalf of the Brazilian Society of Tropical Medicine (BSTM), we present the Second Brazilian Consensus on Chagas Disease, which was developed through intense collaboration among Brazilian experts specialize in different aspects of the disease.
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Can India succeed in eliminating Kala-azar in near future?
Kumari S, Kishjore J. Epidemiology International. 2016; 1(3):3-9.
Abstract This study aimed to assess progress towards elimination of visceral leishmaniasis from India and to identify major challenges in the path of its elimination and to suggest remedial measures to be undertaken to achieve the goal in future. Conclusions included that Kala-azar is very difficult to be eradicated till strategic modifications are not made. Indoor residual spray should be supervised strictly. There is a need for drug compliance and omitting irregular and incomplete treatment.
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Diagnostic tests to support late-stage control programs for schistosomiasis and soil-transmitted helminthiases.
Hawkins KR, Cantera JL, Storey HL et al. PLoS Negl Trop Dis. 2016; 10(12):e0004985.
Abstract There has been increasing recognition within the schistosomiasis and STH communities of the need for improved diagnostic tools to support late-stage control program decisions, such as when to stop or reduce MDA. Based on this analysis, there is a need to develop antigen-detecting rapid diagnostic tests (RDTs) with simplified, field-deployable sample preparation for schistosomiasis. Additionally, there is a need for diagnostic tests that are more sensitive than the current methods for STH, which may include either a field-deployable molecular test or a simple, low-cost, rapid antigen-detecting test.
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Mapping soil transmitted helminths and schistosomiasis under uncertainty: A systematic review and critical appraisal of evidence.
Araujo Navas AL, Hamm NAS et al. PLoS Negl Trop Dis. 2016; 10(12):e0005208.
Abstract Using currently published literature on the spatial epidemiology of helminth infections we identified: (1) the main uncertainty sources, their definition and quantification and (2) how uncertainty is informative for STH programme managers and scientists working in this domain.
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Infection with Schistosoma mansoni has an effect on quality of life, but not on physical fitness in schoolchildren in Mwanza Region, North-Western Tanzania: A cross-sectional study.
Kinung'hi S, Magnussen P, Kaatano G, Olsen A. PLoS Negl Trop Dis. 2016; 10(12):e0005257.
Abstract Of the measured morbidity parameters, S. mansoni infection had a significant effect on the emotional dimension of quality of life, but not on physical fitness. If PedsQL should be a useful tool to measure schistosome related morbidity, more in depth studies are needed in order to refine the tool so it focuses more on aspects of quality of life that may be affected by schistosome infections.
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Differential effect of mass deworming and targeted deworming for soil-transmitted helminth control in children: a systematic review and meta-analysis.
Clarke NE, Clements ACA, Doi SA, Wang D, Campbell SJ, Gray D, Nery SV. Lancet. 2016.
Abstract We aimed to do a systematic review and meta-analysis to compare the effect of mass (community-wide) and targeted (children only) anthelmintic delivery strategies on soil-transmitted helminth prevalence in school-aged children. The results of this meta-analysis suggest that expanding deworming programmes community-wide is likely to reduce the prevalence of soil-transmitted helminths in the high-risk group of school-aged children, which could lead to improved morbidity outcomes.
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The impact of lymphatic filariasis mass drug administration scaling down on soil-transmitted helminth control in school-age children. Present situation and expected impact from 2016 to 2020.
Mupfasoni D, Montresor A, Mikhailov A, King J. PLoS Negl Trop Dis. 2016; 10(12):e0005202.
Abstract Eighty percent of all co-endemic countries that have already stopped LF MDA nationally were able to establish STH PC through schools. It is estimated that 14% of the total number of children presently covered by the LF programme is at risk of not continuing to receive PC for STH. In order to achieve and maintain the WHO 2020 goal for STH control, there is an urgent need to establish and reinforce school-based deworming programmes in countries scaling-down national LF elimination programmes.
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Zika virus: Promoting male involvement in the health of women and families.
Osamor PE, Grady C. PLoS Negl Trop Dis. 2016; 10(12):e0005127.
Abstract Recent heightened media and public health attention to Zika virus (ZIKV) infection has focused on mosquito control, risks to pregnant women, and controversy over the summer Olympics. Missing from these messages is an emphasis on the essential role of men in decisions and behaviors related to ZIKV transmission and outcomes. It is our thesis that the role of men encompasses more than strategies to reduce risk of sexual transmission.
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Investment success in public health: An analysis of the cost-effectiveness and cost-benefit of the Global Programme to Eliminate Lymphatic Filariasis.
Turner HC, Bettis AA, Chu BK et al. Clin. Infect. Dis. 2016.
Abstract The projected cost-effectiveness and cost-benefit of preventive chemotherapy were very promising and this was robust over a very wide range of costs and assumptions. When not including the economic value of the donated drugs, the GPELF would be classed as highly cost-effective.
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Financial burden of health care for Buruli ulcer patients in Nigeria: the patients' perspective.
Chukwu JN, Meka AO, Nwafor CC et al. Int Health. 2016.
Abstract This study assessed the costs of Buruli ulcer care to patients from the onset of illness to diagnosis and to the end of treatment. The median (IQR) direct medical and non-medical cost per patient was US$124 (50-282) and US$3 (3-6); corresponding to 149% and 4% of the patients' median monthly household income, respectively. Direct costs of Buruli ulcer diagnosis and treatment are catastrophic to a substantial proportion of patients and their families.
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Benchmarking the cost per person of mass treatment for selected neglected tropical diseases: An approach based on literature review and meta-regression with web-based software application.
Fitzpatrick C, Fleming FM, Madin-Warburton M et al. PLoS Negl Trop Dis. 2016; 10(12):e0005037.
Abstract The available evidence confirms that mass treatment offers a low cost public health intervention on the path towards universal health coverage. However, more costing studies focussed on elimination are needed. Unit cost benchmarks can help in monitoring value for money in programme plans, budgets and accounts, or in setting a reasonable pay-out for results-based financing mechanisms.
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Spatial distribution of lymphatic filariasis in Cross River state, Nigeria: a geographical information systems (gis) study.
Ukpong I, Davison Mbere-obong J. International Journal of Research – Granthaalayah. 2016; 4(12):101-109.
Abstract This study was aimed at mapping and describing the transmission pattern of lymphatic filariasis in order to identify high risk zones of infection in Cross River State (CRS), to guide intervention programmes. The study has produced prevalence map of LF in the state, which could guide intervention programmes; and has also revealed paucity of data at the disposal of healthcare authorities, a situation that could hinder large scale intervention.
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