Monday, April 16, 2018

(LML) InfoNTD Information on cross-cutting issues in NTDs


Leprosy Mailing List – April 16,  2018

Ref.:   (LML) InfoNTD Information on cross-cutting issues in NTDs

From:  Ilse Egers, Amsterdam, the Netherlands

Dear colleagues,


The newsletter provides you with a selection of news items and recent publications on cross-cutting issues in NTDs. Our starting point is to add articles covering a wide variety of issues. Unfortunately, this is not always possible due to a limited diversity in and shortage of articles on cross-cutting issues and NTDs.

Feel free to contact us with any questions or to receive the PDF if a link to the full text is not included. Our document delivery service is free!

Ilse Egers
InfoNTD Information officer




Video InfoNTD
As you probably know InfoNTD is the international knowledge center for information on cross-cutting issues in Neglected Tropical Diseases. The Coalition for Operational Research on Neglected Tropical Diseases (COR-NTD) produced a video, in cooperation with InfoNTD, that gives you an impression of the website.






New publications



Developing a Buruli ulcer community of practice in Bankim, Cameroon: A model for Buruli ulcer outreach in Africa.
Awah PK, Boock AU, Mou F, et al. PLoS Negl Trop Dis. 2018; 12(3):e0006238.
Abstract In Cameroon, previous efforts to identify Buruli ulcer through the mobilization of community health workers, yielded poor results. In this paper, we describe the successful creation of a BU community of practice in Cameroon composed of hospital staff, former patients, CHWs, and traditional healers.
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The role of community participation for sustainable integrated neglected tropical diseases and water, sanitation and hygiene intervention programs: A pilot project in Tanzania.
Madon S, Malecela MN, Mashoto K, et al. Soc Sci Med. 2018; 202:28-37.
Abstract Strategies aimed at reducing the prevalence of neglected tropical diseases (NTDs) in Tanzania including those attributed to water, sanitation and hygiene (WASH) problems have been largely top-down in nature. They have focused on strengthening the governance of NTD-WASH programs by integrating different vertical disease programs and improving the efficiency of report-generation. In this paper, we argue for community participation as an effective strategy for developing sustainable village health governance.
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The role of gender relations in uptake of mass drug administration for lymphatic filariasis in Alor District, Indonesia.
Krentel A, Wellings K. Parasit Vectors. 2018; 11(1):179.
Abstract The Global Programme to Eliminate Lymphatic Filariasis has set 2020 as a target to eliminate lymphatic filariasis (LF) as a public health problem through mass drug administration (MDA) to all eligible people living in endemic areas. To obtain a better understanding of compliance with LF treatment, a qualitative study using 43 in-depth interviews was carried out in Indonesia. In this paper, we report on the findings specific to the role of family and gender relations and how they affect compliance.
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Psychosocial burden of localised cutaneous Leishmaniasis: a scoping review.
Bennis I, De Brouwere V, Belrhiti Z, et al. BMC Public Health. 2018; 18(1):358.
Abstract Cutaneous Leishmaniasis (CL) is a parasitic skin disease, linked to poverty, and belonging to the group of Neglected Tropical Diseases. Depending on the severity, the type of lesions or scars, and the context, CL can lead to self- and social stigma influencing the quality of life and psychological well-being of the patient. This dimension is, however, little documented for the most common, localized form of cutaneous leishmaniasis (LCL). We aimed to describe the current knowledge on the psychological burden and the stigma related to LCL.
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Knowledge, attitudes and practices regarding urinary schistosomiasis among adults in the Ekombe Bonji Health Area, Cameroon.
Folefa LN, Peter N-F, Verla VS, et al. Pan Afr Med J. 2018; 29:161.
Abstract Urinary schistosomiasis (US) is endemic in Cameroon. Knowledge, attitudes and practices (KAP) are important aspects for control of the disease. However, data on these remain scanty. We aimed at evaluating knowledge, attitudes and practices regarding urinary schistosomiasis among adults in households in the Ekombe Bonji health area.
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The associations between water and sanitation and hookworm infection using cross-sectional data from Togo's national deworming program.
Baker JM, Trinies V, Bronzan RN, et al. PLoS Negl Trop Dis. 2018; 12(3):e0006374.
Abstract Sustainable control of soil-transmitted helminths requires a combination of chemotherapy treatment and environmental interventions, including access to safe drinking water, sufficient water for hygiene, use of clean sanitation facilities, and handwashing (WASH). We quantified associations between home-, school-, and community-level WASH characteristics and hookworm infection-both prevalence and eggs per gram of stool (intensity)-among Togolese school children in the context of community-based chemotherapy treatments administered in the country from 2010 through 2014.
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Evolution of epilepsy prevalence and incidence in a Tanzanian area endemic for onchocerciasis and the potential impact of community-directed treatment with ivermectin: a cross-sectional study and comparison over 28 years.
Greter H, Mmbando B, Makunde W, et al. BMJ Open. 2018; 8(3):e017188.
Abstract In onchocerciasis endemic areas, a distinctive form of epilepsy has been described as nodding syndrome, affecting children and causing nodding seizures, mental retardation and debilitating physical development. Onchocerciasis control programmes using community-directed treatment with ivermectin (CDTI) are implemented in endemic countries. This study is designed to contribute to a better understanding of the linkage between the onset of epilepsy, onchocerciasis and CDTI.
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Delayed versus standard assessment for excision surgery in patients with Buruli ulcer in Benin: a randomised controlled trial.
Wadagni AC, Barogui YT, Johnson RC, et al. Lancet Infect Dis. 2018.
Abstract Surgical intervention was once the mainstay of treatment for Buruli ulcer disease, a neglected tropical disease caused by Mycobacterium ulcerans. Since the introduction of streptomycin and rifampicin for 8 weeks as standard care, surgery has persisted as an adjunct therapy, but its role is uncertain. We investigated the effect of delaying the decision to operate to 14 weeks on rates of healing without surgery.
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Climate change and the neglected tropical diseases.
Booth M. Advances in Parasitology. 2018.
Abstract Climate change is expected to impact across every domain of society, including health. The majority of the world's population is susceptible to pathological, infectious disease whose life cycles are sensitive to environmental factors across different physical phases including air, water and soil. This review offers an introduction into the terms and processes deployed in modelling climate change and reviews the state of the art in terms of research into how climate change may affect future transmission of NTDs.
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From river blindness control to elimination: bridge over troubled water.
Colebunders R, Basáñez M-G, Siling K, et al. Infect Dis Poverty. 2018; 7(1):21.
Abstract An estimated 25 million people are currently infected with onchocerciasis, and 99% of these are in sub-Saharan Africa. The African Programme for Onchocerciasis Control closed in December 2015 and the World Health Organization has established a new structure, the Expanded Special Project for the Elimination of Neglected Tropical Diseases for the coordination of technical support for activities focused on five neglected tropical diseases in Africa, including onchocerciasis elimination.
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Report of the first international workshop on onchocerciasis-associated epilepsy.
Colebunders R, Mandro M, Njamnshi AK, et al. Infect Dis Poverty. 2018; 7(1):23.
Abstract On October 12-142017, the first international workshop on onchocerciasis-associated epilepsy (OAE) was held in Antwerp, Belgium. The workshop was attended by 79 participants from 20 different countries. Recent research findings strongly suggest that O. volvulus is an important contributor to epilepsy, particularly in meso- and hyperendemic areas for onchocerciasis.
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Results of a confirmatory mapping tool for Lymphatic filariasis endemicity classification in areas where transmission was uncertain in Ethiopia.
Sime H, Gass KM, Mekasha S, et al. PLoS Negl Trop Dis. 2018; 12(3):e0006325.
Abstract The goal of the global lymphatic filariasis (LF) program is to eliminate the disease as a public health problem by the year 2020. The WHO mapping protocol that is used to identify endemic areas in need of mass drug administration (MDA) uses convenience-based sampling. In this paper, we present the Ethiopian experience of implementing the new confirmatory mapping tool and discuss the implications of the results for the LF program in Ethiopia and globally.
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What is the impact of water sanitation and hygiene in healthcare facilities on care seeking behaviour and patient satisfaction? A systematic review of the evidence from low and middle income countries.
Bouzid M, Cumming O, Hunter P. BMJ Glob Health. 2018.
Abstract Patient satisfaction with healthcare has clear implications on service use and health outcomes. Barriers to care seeking are complex and multiple and delays in seeking care are associated with significant morbidity and mortality. We sought to assess the relationship between water, sanitation and hygiene (WASH) provision in healthcare facilities and patient satisfaction/ care seeking behaviour in Low and Middle Income Countries.
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Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study.
Abdulai AA, Agana-Nsiire P, Biney F, et al. PLoS Negl Trop Dis. 2018; 12(3):e0006303.
Abstract The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas.
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A decade bibliometric analysis of global research on leishmaniasis in Web of Science database.
Soosaraei M, Khasseh AA, Fakhar M, et al. Ann Med Surg (Lond). 2018; 26:30-37.
Abstract Leishmaniasis is an extremely relevant tropical disease, with global distribution. It still remains a main public health concern in low-income countries, and it is necessary to support more research on this common disease. Thus, a bibliometric analysis of the global scientific production on leishmaniasis was carried out.
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The changing global landscape of health and disease: addressing challenges and opportunities for sustaining progress towards control and elimination of neglected tropical diseases (NTDs).
Molyneux DH, Dean L, Adekeye O, et al. Parasitology. 2018:1-8.
Abstract The drive to control neglected tropical diseases (NTDs) has had many successes but to reach defined targets new approaches are required. Over the last decade, NTD control programmes have benefitted from increased resources, and from effective partnerships and long-term pharmaceutical donations. This paper attempts to address the challenges to end the chronic pandemic of NTDs and achieve the SDG targets.
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Neglected Tropical Disease control - the case for adaptive, location-specific solutions.
Booth M, Clements A. Trends Parasitol. 2018.
Abstract The world is experiencing environmental and social change at an unprecedented rate, with the effects being felt at local, regional, and international scales. This phenomenon may disrupt interventions against neglected tropical diseases (NTDs) that operate on the basis of linear scaling and 'one-size-fits-all'. Here we argue that investment in field-based data collection and building modelling capacity is required.
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Lymphoedema management to prevent acute dermatolymphangioadenitis in podoconiosis (GoLBeT): a pragmatic randomised controlled trial in northern Ethiopia.
Negussie H, Molla M, Ngari M, et al. Lancet Glob Health. 2018.
Abstract Podoconiosis (endemic, non-filarial elephantiasis) affects ~4 million subsistence farmers in tropical Africa. Limited awareness of the condition and lack of evidence for treatment mean that no endemic-country government yet offers lymphoedema management for podoconiosis patients. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: acute dermatolymphangioadenitis episodes.
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Geohelminth infections and associated risk factors among children living in selected shanty (batcher) settlements in Port Harcourt Metropolis, Rivers State, Nigeria.
Chinenye NG, Eze NC, Nduka FO. Int J Trop Dis Health. 2018; 29(1):1-8.
Abstract To determine the prevalence of intestinal parasites and their associated risk factors among children living in some selected shanty settlements in Nigeria, a cross-sectional descriptive study was carried out in Nigeria.
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Implementation of a decentralized community-based treatment program to improve the management of Buruli ulcer in the Ouinhi district of Benin, West Africa.
Amoussouhoui AS, Sopoh GE, Wadagni AC, et al. PLoS Negl Trop Dis. 2018; 12(3):e0006291.
Abstract Mycobacterium ulcerans infection, commonly known as Buruli ulcer (BU), is a debilitating neglected tropical disease. Its management remains complex and has three main components: antibiotic treatment combining rifampicin and streptomycin for 56 days, wound dressings and skin grafts for large ulcerations, and physical therapy to prevent functional limitations after care. In this paper, we report on an innovative pilot program designed to introduce BU decentralization in Ouinhi district, one of Benin's most endemic districts previously served by centralized hospital-based care.
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Re-Imagining Global Health Partnerships in the Sustainable Development Goal (SDG) Era
April 23,  London, UK
Royal Society of Medicine
This half day meeting will gather academics, funders and practitioners from health and development sectors together to discuss how health partnerships can collaborate with and promote inter-disciplinary research.



LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link:

Contact: Dr Pieter Schreuder <<

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