Leprosy Mailing List – April 23, 2018
Ref.: (LML) To differentiate between diabetic neuropathy and pure neuritic leprosy neuropathy
From: Atul Shah, Mumbai; VP Shetty, Mumbai; Wim van Brakel, Amsterdam
The basic question of role of nerve biopsy to rule in or rule out leprosy has not been addressed. Need more clarification on this as well as the site of biopsy.
Whether only electrical methods can conclusively define the DM as the aetiology particularly when all limbs show decreased sensory conduction and one upper limb also has partial motor affection grade 3+ .
Hope to get an insight in these interesting cases.
Thanks. Best regards,
Dr. Atul Shah
President, The Research Society,
Grant Medical College and Sir J J Group of Hospitals, Mumbai
In our experience doing a biopsy of an involved sensory cutaneous nerve and histopathology is the most reliable in diagnosis of suspected pure neural cases of leprosy.
Perhaps to add to what Dr Theuvenet has already written:
· In diabetic neuropathy deep vibration sense is often lost (tuning fork or vibrometer on a bony prominence at the ankle or wrist). In our experience in leprosy, the deep sensation was usually intact.
· In diabetic small fibre neuropathy, cold sensation is affected before warm sensation; our findings in the INFIT cohort study showed that, in persons affected by leprosy, warm detection thresholds were affected more often and earlier than cold sensation.
With kind regards,
Wim van Brakel
Wim van Brakel, MD MSc PhD
Head Technical Department
Netherlands Leprosy Relief (NLR)
Tel. +31 20 5950529
LML - S Deepak, B Naafs, S Noto and P Schreuder
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