Leprosy Mailing List, December 2nd, 2008
Ref.: Steroid therapy in the management of reactions in leprosy.
From: van Brakel W. H., Amsterdam, The Netherlands
Dear Salvatore,
I would like to respond to Prof. Kar's plea (LML Nov. 30th, 2008) for a multi-centre trial to determine an optimal steroid regimen. I fully agree. In fact, a proposal for such a study, called the TENLEP Trials (Treatment of Early Neuropathy in Leprosy), was submitted to four funding organisations in August. This collaborative project combines the efforts of some 10 research centres in 6 countries. The study combines two trials, one to test to prognostic benefit of treating sub-clinical neuropathy detected a diagnosis and the other to find an optimal duration and dosage for steroid treatment of clinical nerve damage of recent onset occurring as part of a Type 1 or 2 reaction or silent neuropathy.
Unfortunately, it appears that the urgency for such a study is not acknowledged everywhere. We have not been able to find sufficient funds to start these trials in 2009. If anyone knows of other funding sources interested to support this research, we would be very happy to hear from them!
With friendly greetings,
Wim van Brakel
Reply email address: w.v.brakel (at) kit.nl
Wim H. van Brakel
KIT Leprosy Unit
Wibautstraat 137 J
1097DN Amsterdam
Netherlands
+3120 6939297
http://www.kit.nl/
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