Erythema nodosum leprosum (ENL) reaction after completion of the 12-month multi-drug therapy (MDT) regimen

Leprosy Mailing List – January 27^th, 2010

Ref.: Erythema nodosum leprosum (ENL) reaction after completion of the 12-month multi-drug therapy (MDT) regimen.

From: B Naafs, Munnekeburen, The Netherlands

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Dear Pran,

I refer to your message dated LML Jan. 23^rd, 2010.

ENL reaction after completion of the 12-month MDT regimen is a well known phenomenon. It happened too when the treatment period was 24 months, but less. It was one of the arguments against the 12 month MDT treatment. But WHO never listens. I have in the past suggested that patients who develop ENL during treatment or are in risk of developing it after treatment, should continue clofazimine for another 1-2 years.

Ben