Monday, October 9, 2017

(LML) Steroid dependency in Leprosy

Leprosy Mailing List – October 8,  2017

Ref.:  (LML) Steroid dependency in Leprosy 

From:  José Augusto, Rio de Janeiro, Brazil


Dear Pieter,



Thank Dr. Grace Warren (LML, 2-10-2017) to bring this important topic to our attention again. The longstanding use of steroids in leprosy (and the resulting dependency) is very worrying and must be well studied and evaluated. In Brazil we have had many problems with the indiscriminate use of this therapy leading to serious side effects and facilitating the appearance of opportunistic diseases of infectious origin. The protocols recommended are in the great majority of the times not followed by the doctors.


I think there must be time and dosage of corticosteroids adjusted for differential use when we have cases with cutaneous involvement and when we have neurological compromise.


Therapeutic behavior with Clofazimine unfortunately still needs to be further studied in endemic countries. However, it should not be forgotten that it also has side effects when used in high doses for an extended time.


Thank you.





Jose Augusto

Dr. José Augusto da Costa Nery


Laboratório de Hanseníase/ ASA

Instituto Oswaldo Cruz - Fiocruz

Av. Brasil 4365, Manguinhos, Rio de Janeiro - RJ CEP 21040-360 - Tels.(21)2562-1588

LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link:

Contact: Dr Pieter Schreuder <<


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