Clofazimine in recurrent type 2 (ENL) leprosy reaction

Leprosy Mailing List – September 3^rd, 2010

Ref.:    Clofazimine in recurrent type 2 (ENL) leprosy reaction.

From:  Indra Napit, Anandaban, Nepal

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Dear Dr. Noto,

Greetings from Anandaban hospital, Nepal.  We also use Clofazimine often for recurrent, chronic or steroid  dependent ENL reactions as many other collegues have mentioned.  It is availbale in our hospital, we buy it from India.

We use following protocol:-

Clofazimine 300 mg daily for 2 months, then 200 mg daily for 2 months and 100 mg daily for 2 months or until the symptoms persists. 

We have realized that Clofazimine helps to reduce the daily requirement of steroids in recurrent  ENL reactions.  Occasionally there is problem of acceptance by patients due to pigmentary changes, dryness of skin and gastrointestinal upset.

I would like to attract your attention on the sentence written by Francesca Gajete from Cebu, Philippines:-  "We get our supply of loose Clofazimine both 100mg and 50 mg capsules from WHO, Geneva, through Dr Steve Lyons".

Can we also get the supply of loose Clofazimine from WHO?

With regards,

Dr. Indra Napit

Medical Superintendent

Anandaban Hospital,

Nepal