Leprosy Mailing List – September 22nd, 2010
Ref.: Clofazimine in ENL
From: Willem Theuvenet, Apeldoorn, The Netherlands
Dear Salvatore,
In addition to the valuable comments of Pieter Schreuders and Ben Naafs (LML Sept. 2nd 2010): I fully agree on their comments. Perhaps a word of caution in those cases of chronic recurrent ENL when a prolonged regime of Clofazamine needs to be combined with corticosteroids. In that situation there is definitely an increased risk of drug induced gastro-intestinal bleeding. This risk is further increased when analgetics are added.
These patients should be carefully monitored for this potential life threatening complication.
With best regards,
Willem Theuvenet
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