Friday, November 13, 2020

Fw: (LML) Clinical Trials need clinical outcomes


 

Leprosy Mailing List – November 13,  2020 

Ref.:  (LML) Clinical Trials need clinical outcomes  

From:  Gerson Penna, Brasilia, Brazil


Dear Pieter,


I would like to emphasize the  comments of Prof. Diana Lockwood, on LML, November 8th 2020, regarding large randomized clinical trials.


The Uniform Multidrug Therapy for leprosy patients in Brazil (U-MDT/CT-BR), which was monitored for many years, presented indeed the robust results expected among multibacillary patients, from an open label, randomized and controlled clinical trial.


The authors are deep connoisseurs on Leprosy, including three senior epidemiologists and as far as we reviewed the literature we did not find, throughout the history of MDT, robust studies equal to the CT conducted by us and to the robust data of the Bangladesh study coordinated by Dr. Ruth Butlin.


In this sense and in the era of evidence-based medicine, alternative leprosy treatment proposals without proven clinical validity are not possible nor desirable.


Best regards,


Gerson Penna

Link CV Lattes

Gerson Penna Lattes

Link Grupo de Medicina Tropical UnB

Gerson Penna Tropical

  

LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << editorlml@gmail.com

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