Friday, November 27, 2020

Fw: (LML) Replacing opinions about leprosy treatment with research


 

Leprosy Mailing List – November 27,  2020

Ref.:  (LML) Replacing opinions about leprosy treatment with research

From:  Vijayaraghavan Radhakrishnan, Chennai, India

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Dear Pieter,


The LML letter of Dr. Narasimba Rao of November 26, 2020 states that: " Yes, I recommend that we need to study the efficacy of daily dose Rifampicin of 10-20 mg/kg.day (max 600 mg)  for 12/24 months (as part of MDT in addition to Dapsone and Clofazimine) in leprosy patients."

 

I would  like to refer to a publication in the Am J Kidney Dis2002 Oct;40(4):690-6. doi: 10.1053/ajkd.2002.35675. " Acute renal failure due to rifampicin: a study of 25 patients" (https://pubmed.ncbi.nlm.nih.gov/12324902/)

 

I may be correct may not be correct, I am not a clinician , I am a Ph.D (Leprosy). I am a non-medical. We have to design a new form of rifampicin like new form of thalidomide (with less genotoxic effect) that will do better.

 

I am not trying to impose my views, when we consider a disease  in terms of clinical approach (ethics comes first), then disinfecting the patient (is the fundamental right of the patient). There are lot of publications that clearly mention the adverse effect of Rifampicin'. Do we need a  new clinical  multicentre trial to test out this suggestion?

 

Vijay

 

Dr. Vijayaraghavan Radhakrishnan. Ph.D (Leprosy),

Chennai (MADRAS)

India

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LML - S Deepak, B Naafs, S Noto and P Schreuder

LML blog link: http://leprosymailinglist.blogspot.it/

Contact: Dr Pieter Schreuder << edit...@gmail.com

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