Leprosy Mailing List – December 19, 2024
Ref.: (LML) Vit D and self-healing in HD
From: Ben Naafs, Munnekeburen, the Netherlands
Dear Pieter,
In addition to the references in the LML letter by Joel Almeida of December 11, 2024, I found another article about Vit D and leprosy:
Am J Med Sci. 2012 Jun;343(6):471-82. doi: 10.1097/MAJ.0b013e318232a6cf.
Role of the vitamin D in leprosy
Khanh vinh quôc Luʼoʼng 1, Lan Thi Hoàng NguyênDOI: 10.1097/MAJ.0b013e318232a6cf
Abstract
There is an evidence of abnormal metabolism in the vitamin D endocrine system of patients with leprosy. Bone deformities usually occur in patients with leprosy. Genetic factors, such as the vitamin D receptor, the major histocompatibility complex region, chromosome 20, human toll-like receptors, the natural resistance-associated macrophage protein 1, the nucleotide-binding oligomerization domain containing 2, phosphate-regulating gene with homologies to endopeptidase on the X chromosome and the tyrosine kinase growth factor receptor-ErbB-2, contribute to both vitamin D status and leprosy. The role of vitamin D in leprosy has been demonstrated by its effects on Bacillus Calmette-Guérin vaccination, vascular endothelial growth factor, prostaglandins, reactive oxygen species, reactive nitrogen intermediates, matrix metalloproteinases, antiphospholipid syndrome and the nerve growth factor. Vitamin D plays a definite role in leprosy. Vitamin D, itself, may effect on leprosy through the vitamin D receptors or may influence leprosy through indirect effects.
Kind regards,
Ben
LML - S Deepak, B Naafs, S Noto and P Schreuder
LML blog link: http://leprosymailinglist.blogspot.it/
Contact: Dr Pieter Schreuder << edit...@gmail.com
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